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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Exploring the Significance of Publication-Age-Based Parameters for Evaluating Researcher Impact
Published 2023“…<p dir="ltr">In the modern era, bibliometric parameters have become crucial components in evaluating academic productivity. In the last three decades, the scientific community has suggested a variety of bibliometric parameters to rank researchers, such as publication count, citation count, author count, h-index, and its variants. …”
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Improved Cognitive Vigilance Assessment after Artifact Reduction with Wavelet Independent Component Analysis
Published 2022“…Mitigating these artifacts is important for an accurate vigilance level assessment. Independent Component Analysis (ICA) is an effective method and has been extensively used in the suppression of EEG artifacts. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…”
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Evidence and gaps in clinical outcomes of novel pharmacologic therapies for sickle cell disease: A systematic literature review highlighting insights from clinical trials and real-...
Published 2025“…Real-world studies of crizanlizumab showed a reduction in complicated VOC events. The high discontinuation rate and results of the STAND trial led to a significant decrease in the use of crizanlizumab. …”
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All-polyethylene versus metal-backed tibial components in total knee arthroplasty: a meta-analysis of randomized controlled trials
Published 2023“…</p><h3>Results</h3><p dir="ltr">A total of 14 RCTs with 1367 TKA were included with a mean age of – years and – years for all-polyethylene and metal-backed tibial components groups, respectively. All-polyethylene group demonstrated statistically significant differences in five-year survivorship (OR 0.27; 95% CI 0.10–0.75; p value 0.01) and stairs climbing score (OR − 2.07; 95% CI − 3.27–0.87; p value 0.0007) when compared to the metal-backed group. …”
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The inhibitory effect of the methanolic extracts of origanum syriacum and rosmarinus officinalis and their major components on the biofilm formation of clinical isolates of staphyl...
Published 2019“…The emergence of bacterial resistance has made treatment of infections more difficult, a reason why a twist towards traditional medication was made as part of the efforts to control such infections. …”
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Better Speed Better Comprehension: Introducing “Integrated Reading Comprehension Strategy
Published 2018“…The findings of the study indicate that IRCS has no statistically significant effects on participants’ reading comprehension and reading speed although all the participants interviewed agree that IRCS enable them to read better and faster. …”
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Metformin attenuates V-domain Ig suppressor of T-cell activation through the aryl hydrocarbon receptor pathway in Melanoma: In Vivo and In Vitro Studies
Published 2021“…VISTA and AHR levels were assessed by qPCR, Western blot, immunofluorescence microscope, flow cytometry, and immunohistochemistry. Here, metformin significantly decreased VISTA and AHR levels in vitro and in vivo. …”
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