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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
Published 2025“…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …”
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Exploring Physical Education Teachers’ Intention and Perceived Constraints in Offering Online Lessons Using the Theory of Planned Behavior: A Multi-Country Analysis
Published 2024“…<div><p>Guided by the theory of planned behavior, this study aimed to determine the influence of Physical Education (PE) teachers’ attitudes, their perceived behavioral control, and the influence of subjective norms on their intention and constraints (intrapersonal, interpersonal, and structural) to offer a high-quality class based on best practices to deliver PE lessons online during the COVID-19 pandemic. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…While most PDAs close after one 3-day course of either medicine, a repeat course may be necessary before considering surgical ligation for those who remain with hsPDAs. In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …”
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Morphological changes in amblyopic eyes in choriocapillaris and Sattler’s layer in comparison to healthy eyes, and in retinal nerve fiber layer in comparison to fellow eyes through...
Published 2021“…Results The method of measuring reflectivity is good to excellent reliability for all regions of interest except the fourth. The mean reflectivity of the choriocapillaris and Sattler’s layer in amblyopic eyes were significantly lower than in healthy eyes (p = 0.003 and p = 0.008 respectively). …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Investigating Educators’ Perceptions of the Impact of STEM Project-Based Learning on 21st Century Skills
Published 2024“…The findings indicate that the 18 items play a significant role in the implementation and practices of STEM PBL to develop 21st century skills.Teachers identified several challenges, such as managing extensive curriculum content, time constraints, limited resources, and difficulties in interdisciplinary collaboration. …”
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A Unified Model-Based Framework for the Simplified Execution of Static and Dynamic Assertion-Based Verification
Published 2020“…In order to simplify its execution, various Model Based System Engineering approaches provide a higher abstraction layer. …”
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Employee Motivation and Job Satisfaction in Project-based Organization: The case of the UAE
Published 2011“…All the organization’s need to focus on employee satisfaction and keep the worker motivated. In case of project based organizations, the subject acquires greater significance as the projects have various constraints and require quality manpower and effort on the part of employees. …”
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Simulation Based Optimization of Logistics Decisions Under Horizontal Collaboration
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Reinforcement Learning Based EV Charging Management Systems–A Review
Published 2021“…Unlike other machine learning approaches, the RL technique is based on maximizing the cumulative reward. This article reviews the existing literature related to the RL-based framework, objectives, and architecture for the charging coordination strategies of electric vehicles in the power systems. …”
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Beyond vanilla: Improved autoencoder-based ensemble in-vehicle intrusion detection system
Published 2023“…Detecting attacks on the CAN bus, particularly masquerade attacks, presents significant challenges. It necessitates an intrusion detection system (IDS) that effectively utilizes both CAN ID and payload data to ensure thorough detection and protection against a wide range of attacks, all while operating within the constraints of limited computing resources. …”
