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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Toxicity assessment of industrial chemicals and airborne contaminants
Published 2005“…Although studying the toxic effects of inhaled chemicals is a complex subject, recent studies demonstrate that in vitro methods may have significant potential for assessing the toxicity of airborne contaminants. …”
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Fungal contamination and mycotoxins in aquafeed and tissues of aquaculture fishes and their biological control
Published 2023“…Both mycotoxins were found in the liver samples, but none of the fish meat (muscle) samples were found to be contaminated with OTA. The in vitro biocontrol co-incubation assay showed that BC344–2 VOCs had a significant inhibitory effect on the growth and sporulation of the three exposed fungi. …”
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Fungal contamination and mycotoxins in aquafeed and tissues of aquaculture fishes and their biological control
Published 2023“…Both mycotoxins were found in the liver samples, but none of the fish meat (muscle) samples were found to be contaminated with OTA. The in vitro biocontrol co-incubation assay showed that BC344–2 VOCs had a significant inhibitory effect on the growth and sporulation of the three exposed fungi. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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An experimental in vitro model for dynamic direct exposure of human cells to airborne contaminants
Published 2006“…Cytotoxicity of the test gas was investigated using the MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium), NRU (neutral red uptake) and ATP (Adenosine triphosphate) assays. Dose-dependent effects of NO2 were observed in human cells tested which resulted in a significant reduction of cell viability at concentrations normally encountered in workplace environments (p < 0.05). …”
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Arsenic contamination in rice: a DPSIR analysis with a focus on top rice producers
Published 2025“…<p>Arsenic contamination in rice poses significant risks to public health and food security. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Immobilization of copper, lead, and tungsten in mixed munitions firing range–contaminated soils by various amendments
Published 2011“…Flow-through column tests were conducted for one of the soil samples to test the effectiveness of GFO to immobilize Cu, Pb, and W. The concentrations of Cu, Pb, and W were significantly reduced in the effluent of the amended soil columns as compared with the control soil columns.…”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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Investigation of a fecal contamination of groundwater and surface water at Al Wasit Nature Reserve, Sharjah, United Arab Emirates
Published 2016“…Domestic waste contamination has adverse health effects and detrimental ecological impact. …”
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Exploring the dynamics of algae-associated microbiome during the scale-up process of Tetraselmis sp. microalgae: A metagenomics approach
Published 2024“…Microbial profiling of each successive stage revealed lower abundance of eukaryotic organisms, whereas bacterial abundance increased notably resulting in a significant decrease in Tetraselmis sp. abundance. …”