Discovery of Dual-Acting Biofilm Inhibitors against Pseudomonas aeruginosa by the Coupling of 3‑Hydroxypyridin-4(1<i>H</i>)‑ones with <i>N</i>‑Phenylamide QS Inhibitors by Hao-Zhong Long (19685972)

“…Herein, a series of novel dual-acting biofilm inhibitors were designed and synthesized by coupling 3-hydroxypyridin-4(1<i>H</i>)-ones with <i>N</i>-phenylamides quorum sensing inhibitors. The hit compound <b>19l</b> (IC₅₀ = 0.33 ± 0.06 μM) demonstrated significant biofilm inhibition compared to previously reported 3-hydroxypyridin-4(1<i>H</i>)-one derivatives <i>in vitro</i>. …”

Data Sheet 1_Integrated computational and experimental identification of N-[(1H-1,2,4-triazol-3-yl)phenyl]-1-(1H-pyrazolo[3,4-b]pyridin-3-yl)methanamide as a potent and selective T... by Xinxin Ying (21507500)

“…Survival analysis revealed a significant correlation between elevated TIM-3 expression and decreased patient survival. …”

Movement variability conditioned on task outcome. by Adam M. Roth (19845864)

Delta <i>CC</i> heatmap. by Curtis Chepsiror (21368103)

RMSF. by Curtis Chepsiror (21368103)

AMP binding free energy calculations and per-residue decomposition of holo and PfIleRS-SANC systems. by Curtis Chepsiror (21368103)

Fig 9 - BC. by Curtis Chepsiror (21368103)

Fig 10 - EC. by Curtis Chepsiror (21368103)

Targeting of Vps34 reduces B16F10 tumor growth and working model for Vps34-dependent regulation of eTreg transitional heterogeneity and maintenance. by Erienne G. Norton (9612079)

PfIleRS-SANC456 delta <i>CC.</i> by Curtis Chepsiror (21368103)

We compared the Fugl-Meyer (FMA) clinical assessment scores for individuals with stroke with their performance for each outcome measure. by Devin Sean Austin (20285144)

Alternative representation of daunorubicin fluorescence testing of novel inhibitors. by Lauren A. McCormick (20540638)

Amino acid metabolic pathways are influenced by the NC1 POM cycle over expression. by Bonnie A. McNeil (22331601)

“…The size of each circle reflects the number of “hits” relevant to the pathway with red having higher and yellow having lower significance based on <i><i>p</i></i>-value score.…”

Hybrid Molecules of Benzothiazole and Hydroxamic Acid as Dual-Acting Biofilm Inhibitors with Antibacterial Synergistic Effect against Pseudomonas aeruginosa Infections by Zhen-Meng Zhang (20874497)

“…Moreover, <b>JH21</b> significantly enhanced the efficacy of tobramycin and ciprofloxacin by 200- and 1000-fold, respectively, in a mouse wound infection model. …”

PERCOM, an unbiased and easily-accessible protein-centric analysis workflow. by Brian Foo (19273132)

Graphical overview of study. by Brian Foo (19273132)

Supplementary Material for: Placebo effect of verbal instructions coupled with pharmacological treatment: results from a randomized controlled trial in migraine patients by figshare admin karger (2628495)

“…Results: Patients who received strongly positive instructions had no HIT decrease (p = 0.177; η2 = 0.034). Patients who received positive instructions had HIT decrease (p = 0.006; η2 = 0.770). …”

TgHCF101 is involved in Fe-S cluster biogenesis of the CIA pathway. by Eléa A. Renaud (18192764)

“…Cut-offs were set at ≤1.5- or ≥1.5-fold change (FC) and <i>p</i>-value ≤0.05. Significant hits corresponding to predicted Fe-S cluster proteins are highlighted in red on the graph. …”

Table 1_Ribosomes binding to TAS transcripts buffer ta-siRNA biogenesis in Arabidopsis thaliana.docx by Han Wang (254423)

“…Utilizing edited TAS genes in Arabidopsis, a combination of sRNA-seq, mRNA-seq, RIP-seq, and degradome-seq was employed to investigate the role of ribosomes in ta-siRNA biogenesis in this study. In the two-hit model, deletion of ribosome-binding regions resulted in a decrease in the abundance of intact TAS3 transcripts but did not significantly affect ta-siRNAs production or the efficiency of miRNA-guided cleavage. …”

Table 2_Ribosomes binding to TAS transcripts buffer ta-siRNA biogenesis in Arabidopsis thaliana.xlsx by Han Wang (254423)

“…Utilizing edited TAS genes in Arabidopsis, a combination of sRNA-seq, mRNA-seq, RIP-seq, and degradome-seq was employed to investigate the role of ribosomes in ta-siRNA biogenesis in this study. In the two-hit model, deletion of ribosome-binding regions resulted in a decrease in the abundance of intact TAS3 transcripts but did not significantly affect ta-siRNAs production or the efficiency of miRNA-guided cleavage. …”