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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Robust design of electrical power-based stabilizers using tabusearch
Published 2001Get full text
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Design and Development of Inexpensive Paper-Based Chemosensors for Detection of Divalent Copper
Published 2023“…In view of the above advantages, a novel and the highly sensitive paper-based sensor has been designed for the selective detection of Cu<sup>2+</sup> ions. …”
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Modified Elite Opposition-Based Artificial Hummingbird Algorithm for Designing FOPID Controlled Cruise Control System
Published 2023“…This study proposes a novel approach for designing a fractional order proportional-integral-derivative (FOPID) controller that utilizes a modified elite opposition-based artificial hummingbird algorithm (m-AHA) for optimal parameter tuning. …”
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Efficient experimental design for uncertainty reduction in gene regulatory networks
Published 2015“…Gene regulatory networks often contain a significant amount of uncertainty. The process of prioritizing biological experiments to reduce the uncertainty of gene regulatory networks is called experimental design. …”
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Decision Support Model for Optimal Design of Wind Technologies Based Techno–Economic Approach
Published 2021“…<p dir="ltr">This paper aims to propose a practical decision support model for the optimal design of future wind turbines based on available wind potential on the site of interest. …”
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The Development And Significance Of Business Intelligence (BI) Platforms In Facilitating The Decision-Making Process In Dubai Government Entities
Published 2022“…Using secondary research design, the study determined factors that impact the decision-making process in Dubai government entities. …”
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An effectuation and causation perspective on the role of design thinking practices and digital capabilities in platform-based ventures
Published 2023“…Based on a survey of 291 platform-based start-ups in India, the results show that design thinking ways are well integrated into the theories of effectuation and causation, facilitating the growth of platform-based ventures. …”
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Accelerating the Design of Photocatalytic Surfaces for Antimicrobial Application: Machine Learning Based on a Sparse Dataset
Published 2021“…This machine-learning-assisted strategy offers the opportunity to reduce the cost, labor, time, and precursors consumed during experiments that are based on trial and error. Our strategy may significantly accelerate the large-scale deployment of photocatalysts as a promising route to mitigate fomite transmission of pathogens (bacteria, viruses, fungi) in hospital settings and public places.…”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …”