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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
Published 2025“…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…While most PDAs close after one 3-day course of either medicine, a repeat course may be necessary before considering surgical ligation for those who remain with hsPDAs. In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Econometric Modeling of Gasoline Consumption
Published 2008“…Finally, statistical performance measures, such as mean square error, mean average deviation, and mean average percentage error, are presented for all models.…”
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Shear Behavior of One-Way Reinforced Concrete Hollow Slabs Voided with PET Void Formers
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Econometric modeling of electricity consumption in post-war Lebanon
Published 2000“…Finally, statistical performance measures such as mean square error, mean average deviation and mean average percentage error are presented for all models.…”
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Site-Adaptation of Modeled Solar Radiation Data: The SiteAdapt Procedure
Published 2020“…It was tested at nine sites in a wide range of latitudes and climates, resulting in significant improvements of statistical indicators of dispersion, distribution similarity and overall performance: relative bias is reduced on average from −1.8% and −2.3% to 0.1% and 0.3% for GHI and DNI, respectively; relative root mean square deviation is reduced on average from 17.9% and 34.9% to 14.6% and 29.8% for GHI and DNI, respectively; the distribution similarity is also improved after the site-adaptation (KSI is 3.5 and 3.9 times lower for GHI and DNI at hourly scale, respectively). …”
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Modelling of Asphalt’s Adhesive Behaviour Using Classification and Regression Tree (CART) Analysis
Published 2019“…<p>The modification by polymers and nanomaterials can significantly improve different properties of asphalt. …”
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Do commodity price volatilities impact currency misalignments in commodity-exporting countries?
Published 2020“…Then, we rely on panel data and a smooth-transition regression model to estimate commodity price volatilities' non-linear impacts on currency misalignments. …”
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A coupled finite element EHL and continuum damage mechanics model for rolling contact fatigue
Published 2017“…The results demonstrate that the damage variable has a significant effect on pressure distribution within the contact and depending on the level of damage; the pressure distribution can significantly deviate from the undamaged EHL pressure. …”
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Scatter search for protein structure prediction. (c2008)
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Forecasting Emerging Stock Market Crashes via Machine Learning
Published 2023Get full text
doctoralThesis