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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…In this regard, engineering of brighter bioluminescent proteins, i.e. luciferases, has played a significant role. This is acutely exemplified by the engineering of the NLuc <u>luciferase</u>, which is small in size and displays much enhanced bioluminescence and<u> thermal stability</u> compared to previously available luciferases. …”
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Understanding dispute resolution in the Middle East region from perspectives of different stakeholders
Published 2016“…However, this growth is accompanied by an inevitable increase in claims and disputes, which consequently leads to significant delays and additional costs to the project. …”
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Comparative analysis of environmental, social and governance (ESG) ratings: do sectors and regions differ
Published 2024“…In terms of industry, transportation infrastructure and media, both categorized under low ESG risk, portray a statistically significant difference from other industries. Finally, the sector wise reports clearly evince an overall statistically significant difference between financial and non-financial sector in all regions, the former presenting high risk ESG scores in Asia and North America. …”
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Comparative analysis of environmental, social and governance (ESG) ratings: do sectors and regions differ?
Published 2024“…In terms of industry, transportation infrastructure and media, both categorized under low ESG risk, portray a statistically significant difference from other industries. Finally, the sector wise reports clearly evince an overall statistically significant difference between financial and non-financial sector in all regions, the former presenting high risk ESG scores in Asia and North America. …”
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Gender differences at work
Published 2015“…There may be a considerable amount of research on this topic in developed countries; however, there have been very few in the Middle East region. This research study aims to explore gender differences in the experiences of human resource (HR) management (HRM) policies in the workplace. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Developing Power-Law Fluid Flow in The Entrance Region of a Parallel Plate Channel
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Hemodynamics of small aneurysm pairs at the internal carotid artery
Published 2012“…The maximum wall shear stress increases for serial aneurysms, but decreases for parallel aneurysms. Interaction between parallel aneurysms is not significant; however, the proximal aneurysm in serial aneurysms may be subject to a greater rupture risk.…”
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Suppression of Unstable Flow by Using Rough Surfaces at Small Mass Flow Rates in a Radial Diffuser
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Staff Development: A Study Into The Significance of Staff Professional Development Programs for Educators and Students Achievement
Published 2011“…Several authors/ researchers have made an attempt to touch upon the different dimensions associated with PD programs. This dissertation attempts to study the significance of staff professional development for educators and how it can affect students’ achievement. …”
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Effect of corporate ethics and social responsibility on OCB: the role of employee identification and perceived CSR significance
Published 2021“…The proposed model depicting the relationships is tested empirically based on data collected from a survey instrument distributed to alumni from one of the leading universities in Lebanon employed in various companies belonging to different sectors in Lebanon and the region. Partial least square structural equation modeling (PLS-SEM) is used to analyze the data and multi-group analysis is conducted to investigate the role of perceived CSR significance. …”
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Economic development and sub-regional identities
Published 2015“…The results indicate that explanatory variables responded differently in each group, which indicates the significant effect of the identities used to determine the division of the regions. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …”
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