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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…In this regard, engineering of brighter bioluminescent proteins, i.e. luciferases, has played a significant role. This is acutely exemplified by the engineering of the NLuc <u>luciferase</u>, which is small in size and displays much enhanced bioluminescence and<u> thermal stability</u> compared to previously available luciferases. …”
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Estimating hydrogen absorption energy on different metal hydrides using Gaussian process regression approach
Published 2022“…<p dir="ltr">Hydrogen is a promising alternative energy source due to its significantly high energy density. Also, hydrogen can be transformed into electricity in energy systems such as fuel cells. …”
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Machine Learning Based Photovoltaics (PV) Power Prediction Using Different Environmental Parameters of Qatar
Published 2019“…The ANN model outperforms other regression models, such as a linear regression model, M5P decision tree and gaussian process regression (GPR) model. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Hemodynamics of small aneurysm pairs at the internal carotid artery
Published 2012“…The maximum wall shear stress increases for serial aneurysms, but decreases for parallel aneurysms. Interaction between parallel aneurysms is not significant; however, the proximal aneurysm in serial aneurysms may be subject to a greater rupture risk.…”
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Suppression of Unstable Flow by Using Rough Surfaces at Small Mass Flow Rates in a Radial Diffuser
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Ensemble Deep Random Vector Functional Link Neural Network for Regression
Published 2022“…<p dir="ltr">Inspired by the ensemble strategy of machine learning, deep random vector functional link (dRVFL), and ensemble dRVFL (edRVFL) has shown state-of-the-art results on different datasets. Our present work first fills the gap of dRVFL and edRVFL work in the field of regression. …”
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Modelling of Asphalt’s Adhesive Behaviour Using Classification and Regression Tree (CART) Analysis
Published 2019“…<p>The modification by polymers and nanomaterials can significantly improve different properties of asphalt. …”
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Kernel-Ridge-Regression-Based Randomized Network for Brain Age Classification and Estimation
Published 2024“…Moreover, the proposed algorithm demonstrated excellent prediction accuracy with a mean absolute error (MAE) of <b>3.89</b> years, <b>3.64 </b>years, and <b>4.49</b> years for GM, WM, and CSF regions, confirming that changes in WM volume are significantly associated with normal brain aging. Additionally, voxel-based morphometry (VBM) examines age-related anatomical alterations in different brain regions in GM, WM, and CSF tissue volumes.…”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …”
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A flexible genetic algorithm-fuzzy regression approach for forecasting: The case of bitumen consumption
Published 2019“…Moreover, the fuzzy regression (FR) model is used for estimation. Analysis of variance (ANOVA) is used for selecting among GA, FR or conventional regression (CR). …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …”
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Small molecule inhibition of stat3 enhances survival in mice with intracerebral melanoma
Published 2008“…In addition, WP1066 decreased the level of c-Myc and survivin in melanoma cells in a dose- and time-dependent manner. …”
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