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Metal–Organic Framework-Based Drug Delivery Systems for Cancer Therapy: A Review
Published 2026“…Cancer remains one of the most significant global health challenges, with conventional treatments limited by side effects and resistance to drugs. …”
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Novel platinum(II)-based anticancer complexes and molecular hosts as their drug delivery vehicles
Published 2007“…Encapsulation by CB[6] was found to not significantly change the cytotoxicity of five platinum(II)-based DNA intercalators, indicating it may have utility as a molecular carrier for improved drug delivery.…”
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Novel Natural Based Chewable Lozenges for the Treatment of Erectile Dysfunction
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pH and ultrasound dual-responsive drug delivery system based on PEG–folate-functionalized Iron-based metal–organic framework for targeted doxorubicin delivery
Published 2021“…In this work, dual-responsive iron-based MOFs were synthesized via the microwave-assisted method using FeCl₃.6 (H₂O) as the metal cluster and 2-aminoterephthalic acid (NH₂-BDC) as the organic linker (namely NH₂-Fe-BDC) and loaded with the anti-cancer drug doxorubicin (DOX). …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Whole-genome sequencing based molecular characterization of multi-drug resistant isolates of Enterobacter spp. and Klebsiella aerogenes in Lebanon. (c2019)
Published 2019“…They are commonly notorious for causing healthcare-associated infections and impose a significant burden on secondary health-centers. In the last few decades, the rise of ECC and K. aerogenes as successful nosocomial pathogens was paralleled by the global alarming emergence of multi-drug resistant clones of these bacteria. …”
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Promising approaches for controlled pulmonary drug delivery
Published 2015“…Micro- and nanoparticles-based drug delivery systems could potentially improve the delivery of inhaled drugs significantly, because they can be designed in specific shapes and sizes, and with certain other properties that optimize their bioavailability. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …”
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Efficacy and Safety of Colistin versus Tigecycline for Multi-Drug-Resistant and Extensively Drug-Resistant Gram-Negative Pathogens—A Meta-Analysis
Published 2022“…<h3>Background</h3><p dir="ltr">We intended to compare the efficacy and safety outcomes of colistin versus tigecycline as monotherapy or combination therapy against multi-drug resistant (MDR) and extensively drug-resistant (XDR) pathogens. …”
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Machine Learning Techniques for Pharmaceutical Bioinformatics
Published 2018“…The study integrates knowledge visualization, analysis, as well as development of a predictive model based on the Drug-Drug Interactions (DDIs) as a complex network. …”
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Functionalized Metal Organic Frameworks For Chemotherapy Drug Delivery
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Deep Learning for the Accurate Prediction of Triggered Drug Delivery
Published 2024“…The deep learning-based predictions significantly outperform linear predictions, proving the utility of advanced computational methods in drug delivery. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
Published 2025“…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …”
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