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Metal–Organic Framework-Based Drug Delivery Systems for Cancer Therapy: A Review
Published 2026“…Cancer remains one of the most significant global health challenges, with conventional treatments limited by side effects and resistance to drugs. …”
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Novel platinum(II)-based anticancer complexes and molecular hosts as their drug delivery vehicles
Published 2007“…Encapsulation by CB[6] was found to not significantly change the cytotoxicity of five platinum(II)-based DNA intercalators, indicating it may have utility as a molecular carrier for improved drug delivery.…”
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Novel Natural Based Chewable Lozenges for the Treatment of Erectile Dysfunction
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pH and ultrasound dual-responsive drug delivery system based on PEG–folate-functionalized Iron-based metal–organic framework for targeted doxorubicin delivery
Published 2021“…In this work, dual-responsive iron-based MOFs were synthesized via the microwave-assisted method using FeCl₃.6 (H₂O) as the metal cluster and 2-aminoterephthalic acid (NH₂-BDC) as the organic linker (namely NH₂-Fe-BDC) and loaded with the anti-cancer drug doxorubicin (DOX). …”
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Whole-genome sequencing based molecular characterization of multi-drug resistant isolates of Enterobacter spp. and Klebsiella aerogenes in Lebanon. (c2019)
Published 2019“…They are commonly notorious for causing healthcare-associated infections and impose a significant burden on secondary health-centers. In the last few decades, the rise of ECC and K. aerogenes as successful nosocomial pathogens was paralleled by the global alarming emergence of multi-drug resistant clones of these bacteria. …”
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Promising approaches for controlled pulmonary drug delivery
Published 2015“…Micro- and nanoparticles-based drug delivery systems could potentially improve the delivery of inhaled drugs significantly, because they can be designed in specific shapes and sizes, and with certain other properties that optimize their bioavailability. …”
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Efficacy and Safety of Colistin versus Tigecycline for Multi-Drug-Resistant and Extensively Drug-Resistant Gram-Negative Pathogens—A Meta-Analysis
Published 2022“…<h3>Background</h3><p dir="ltr">We intended to compare the efficacy and safety outcomes of colistin versus tigecycline as monotherapy or combination therapy against multi-drug resistant (MDR) and extensively drug-resistant (XDR) pathogens. …”
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Machine Learning Techniques for Pharmaceutical Bioinformatics
Published 2018“…The study integrates knowledge visualization, analysis, as well as development of a predictive model based on the Drug-Drug Interactions (DDIs) as a complex network. …”
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Functionalized Metal Organic Frameworks For Chemotherapy Drug Delivery
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Deep Learning for the Accurate Prediction of Triggered Drug Delivery
Published 2024“…The deep learning-based predictions significantly outperform linear predictions, proving the utility of advanced computational methods in drug delivery. …”
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High-amylose carboxymethyl starch matrices for oral sustained drug-release
Published 2016“…Until now, their controlled-release properties have been assessed only by an in vitro dissolution test. Amylose-based polymers are normally subject to biodegradation by α-amylase enzymes present in the gastrointestinal tract, but matrix systems show no significant degradation of tablets by α-amylase in vitro. …”
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Nanoparticle enrichment mass-spectrometry proteomics identifies protein-altering variants for precise pQTL mapping
Published 2024“…<p dir="ltr">Proteogenomics studies generate hypotheses on protein function and provide genetic evidence for drug target prioritization. Most previous work has been conducted using affinity-based proteomics approaches. …”
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Physicochemical studies of binary eutectic of ibuprofen and ketoprofen for enhanced transdermal drug delivery
Published 2010“…The NSAID membrane flux values were calculated by flux ratio equations based on drug thermodynamic data, and compared to experimental values obtained from permeation studies. …”
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Plasma Bead Entrapped Liposomes as a Potential Drug Delivery System to Combat Fungal Infections
Published 2022“…<div><p>Fibrin-based systems offer promises in drug and gene delivery as well as tissue engineering. …”
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Morphological changes in amblyopic eyes in choriocapillaris and Sattler’s layer in comparison to healthy eyes, and in retinal nerve fiber layer in comparison to fellow eyes through...
Published 2021“…Results The method of measuring reflectivity is good to excellent reliability for all regions of interest except the fourth. The mean reflectivity of the choriocapillaris and Sattler’s layer in amblyopic eyes were significantly lower than in healthy eyes (p = 0.003 and p = 0.008 respectively). …”
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Thalidomide-Revisited: Are COVID-19 Patients Going to Be the Latest Victims of Yet Another Theoretical Drug-Repurposing?
Published 2020“…Yet, the absence of substantial evidence on Thalidomide usage in that context along with the discontinued studies on the efficiency of this drug in similar pulmonary diseases, might cause a significant obstacle for carrying out further clinical evaluations. …”
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A population study of clinically actionable genetic variation affecting drug response from the Middle East
Published 2022“…The allele frequencies of 1,320 variants in 703 genes affecting 299 drugs or class of drugs were significantly different between the Qatari population and other world populations. …”
