Promising approaches for controlled pulmonary drug delivery by Nature Research (16552612)

“…Micro- and nanoparticles-based drug delivery systems could potentially improve the delivery of inhaled drugs significantly, because they can be designed in specific shapes and sizes, and with certain other properties that optimize their bioavailability. …”

The Effect of Ultrasound on the Drug Delivery of RGD-Targeted Liposomes by Mahmoud, Mohamad

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Distribution of Doxorubicin in Rats Undergoing Ultrasonic Drug Delivery by Staples, Bryant J.

“…Ultrasound (US) increases efficacy of drugs delivered from micelles, but the pharmacokinetics have not been studied previously. …”
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Deep Learning for the Accurate Prediction of Triggered Drug Delivery by Husseini, Ghaleb

“…The deep learning-based predictions significantly outperform linear predictions, proving the utility of advanced computational methods in drug delivery. …”
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Lipsome-coated metal organic frameworks as a new drug nanocarrier by Mohamed, Omnia A.

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Physicochemical studies of binary eutectic of ibuprofen and ketoprofen for enhanced transdermal drug delivery by Capomacchia, Anthony Cesare

“…Results: The DSC studies showed that melting point (61°C), enthalpy (11.3 kJ/mol), and entropy of fusion (33.7 J/K/mol) of the binary eutectic were significantly lower than those of the individual anti-inflammatory drugs (NSAIDs). …”
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Anti-cancer Drug Delivery Using Metal Organic Frameworks (MOFs) and Ultrasound. by Ibrahim, Mihad

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Strategies for the production of long-acting therapeutics and efficient drug delivery for cancer treatment by Alanod D. AlQahtani (18805930)

“…These two techniques improve stability, reduce immunogenicity, and increase drug resistance to proteases. These factors lead to the reduction of injection frequency which increases patient compliance and improve quality of life. …”

The Impact of a Computerized Potassium Alert on Adverse Drug Events and Pharmacists' Interventions by Mansour, Hanine

“…Conclusions: Implementation of a computerized pharmacy alert resulted in a statistically significant decrease in adverse drug events related to hyperkalemia in our institution. …”
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Photoactivatable RuII Complex Bearing 2,9‐Diphenyl‐1,10‐phenanthroline: Unusual Photochemistry and Significant Potency on Cisplatin‐Resistant Cell Lines by Mansour, Najwa

“…In conclusion, the Ru‐centered complex 1 could represent a potential photoactivatable chemotherapeutic drug that increases selectivity to tumors and offers alternative treatment in the light of increasing cisplatin resistance.…”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells by Shebaby, Wassim N.

“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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Increased Frequency of Severe Hypoglycemia with the Modified-Release Gliclazide Compared to Glimepiride in Diabetic Older Adults; Propensity Score-Adjusted Analysis by Ahmed Fouad Algendy (18102706)

“…We compared baseline differences between cohorts in demographics, lab results, diabetes complications, comorbidities, and drugs using the chi-squared test for categorical variables and unpaired t-test for continuous variables. …”

The Use of Transferrin and Ultrasound in Cancer Treatment by AlSawaftah, Nour Majdi

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Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance by Gh Rasool Bhat (13038132)

“…This diversity, known as cancer cell plasticity, confers cancer cells the ability to change in response to their environment, leading to increased tumor diversity and drug resistance. This review explores the intricate landscape of cancer cell plasticity, offering a deep dive into the cellular, molecular, and genetic mechanisms that underlie this phenomenon. …”

Morphological changes in amblyopic eyes in choriocapillaris and Sattler’s layer in comparison to healthy eyes, and in retinal nerve fiber layer in comparison to fellow eyes through... by Masri, Oussama Samer

“…Results The method of measuring reflectivity is good to excellent reliability for all regions of interest except the fourth. The mean reflectivity of the choriocapillaris and Sattler’s layer in amblyopic eyes were significantly lower than in healthy eyes (p = 0.003 and p = 0.008 respectively). …”
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Ultrasound-responsive Nanocarriers in Cancer Treatment: a review by Awad, Nahid S.

“…The safe and effective delivery of anticancer agents to diseased tissues is one of the significant challenges in cancer therapy. Conventional anticancer agents are generally cytotoxins with poor pharmacokinetics and bioavailability. …”
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A population study of clinically actionable genetic variation affecting drug response from the Middle East by Puthen Veettil Jithesh (12040358)

“…The allele frequencies of 1,320 variants in 703 genes affecting 299 drugs or class of drugs were significantly different between the Qatari population and other world populations. …”

Influence of physicochemical properties on the in vitro skin permeation of the enantiomers, racemate, and eutectics of ibuprofen for enhanced transdermal drug delivery by Capomacchia, Anthony C.

“…Physicochemical properties of chiral ibuprofen are significant to formulation scientists because its enantiomers and eutectics possess lower melting points than its racemate. …”
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Evidence and gaps in clinical outcomes of novel pharmacologic therapies for sickle cell disease: A systematic literature review highlighting insights from clinical trials and real-... by Mohamed Yassin (4166515)

“…The high discontinuation rate and results of the STAND trial led to a significant decrease in the use of crizanlizumab. The HOPE trial demonstrated a 51 % improvement in hemoglobin response and a reduction in hemolytic markers in patients treated with voxelotor. …”

DNA damage induced by micellar-delivered doxorubicin and ultrasound: comet assay study by Husseini, Ghaleb

“…However, when ultrasound was applied, a rapid and significant increase in DNA damage was observed (P=0.0001). …”
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