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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
Published 2025“…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …”
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Editorial: Special Issue - Economics in Digital Construction
Published 2024“…These advancements promise substantial economic benefits, ranging from increased productivity to enhanced decision-making capabilities, which, in turn, can spur significant growth in the broader economy. …”
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Economic policy uncertainty: Global energy security with diversification
Published 2024“…This study also demonstrates that labor capital shifts have a significant effect on ED. The quantitative results reveal the importance of clear and precise economic policies for increasing investment in carbon-free energy security.…”
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Techno-Economic Analysis of Autotrophic Microalgae for Biofuel Production in India
Published 2013“…Modern society relies on non-renewable sources of energy which is the dominant source of energy, which accounts for nearly 84% of the overall increase in demand between 2005 and 2030 (Khan et al., 2009). …”
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Estimating Economic and Environmental Benefits of Urban Trees in Desert Regions
Published 2020“…<p>Trees in urban areas have a significant impact on air quality and other environmental issues. …”
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Revisiting the economic theory of crime A state-level analysis in India
Published 2023“…<p dir="ltr">The economic theory of crime tends to suggest that deterrence variables have a significant impact on crime rates in a society. …”
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Evaluating the economic impact of clinical pharmacist interventions in the women’s health setting in Qatar
Published 2025“…The sensitivity analysis confirmed that the outcomes are robust, demonstrating a 100% probability for positive economic benefits in all simulated cases.</p><h3>Conclusion</h3><p dir="ltr">Although there was an observed increase in resource utilization resulting from clinical pharmacists’ interventions, this study highlights their crucial role in mitigating the costs associated with preventable adverse drug events.…”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…While most PDAs close after one 3-day course of either medicine, a repeat course may be necessary before considering surgical ligation for those who remain with hsPDAs. In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …”
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Thermo-economic Optimization of Hybrid Combined Power Cycles Using Heliostat Field Collector
Published 2016Get full text
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A Stackelberg Game Inspired Model of Real-Time Economic Dispatch with Demand Response
Published 2021Get full text
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