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Discover: across the spectrum of grades
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Validating a Structural Model of Destination Image, Satisfaction, and Loyalty Across Gender and Age
Published 2015“…This study validates an interesting model of destination image (DI), tourist satisfaction, and loyalty across gender and age. We confirm that DI predicts satisfaction and has a significant direct and indirect effect on loyalty. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Effect of lifestyle intervention on HbA1c levels in overweight and obese adults with type 2 diabetes across ethnicities: A systematic review and meta-analysis of randomized control...
Published 2023“…Notably, a significantly beneficial effect on HbA1c was observed in White/Caucasians (WMD = -0.59, 95% CI: −0.90, −0.28, P < 0.001) and Asians (WMD = -0.48, 95% CI: −0.63, −0.33, P < 0.001), but not in the Black/African or Hispanic group (both P > 0.05). …”
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Deep random vector functional link transformer network with multiple output layers for significant wave height forecasting
Published 2025“…The computational results demonstrate the superiority of the proposed models through a comparative analysis against state-of-the-art approaches across fifteen significant wave height time series, validated by three error metrics and a statistical test.…”
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A Real-Time Energy Management System Across Diverse Energy Sectors in Smart Cities
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Diagnostic accuracy of interleukin-6 (IL-6) as a significant biomarker in late-onset neonatal sepsis: an updated systematic review and meta-analysis
Published 2025“…Subgroup and sensitivity analyses confirmed the robustness of the findings, and no significant threshold effect was detected. However, suspected publication bias was noted. …”
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Impacts of twenty years of experimental warming on soil carbon, nitrogen, moisture and soil mites across alpine/subarctic tundra communities
Published 2022“…<p>High-altitude and alpine areas are predicted to experience rapid and substantial increases in future temperature, which may have serious impacts on soil carbon, nutrient and soil fauna. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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Effects of paternal and chronological age on BEGAIN methylation and its possible role in autism
Published 2023“…<p dir="ltr">Children from old fathers carry an increased risk for autism spectrum (ASD) and other neurodevelopmental disorders, which may at least partially be mediated by paternal age effects on the sperm epigenome. The brain enriched guanylate kinase associated (BEGAIN) protein is involved in protein-protein interactions at and transmission across synapses. …”
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A Cross-cultural study of pragmatically requestive speech act realization patterns
Published 2014“…This study provides implications to the students, teachers, educational syllabus designers, decision makers, authors for preventing pragmatic failure/ error to happen and for facilitating effective communications across cultures, too.…”
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Exploring the Impact of Technology-Enabled Pedagogies on the Effectiveness of Students’ Learning
Published 2024“…Although acknowledging limitations due to varied technological infrastructure across institutions, the study concludes that embracing technology-enabled pedagogies is essential for modern education, offering significant advantages in personalizing learning experiences and preparing students with crucial 21st-century skills.…”
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