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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Detection of statistically significant network changes in complex biological networks
Published 2017“…</p><h3>Conclusions</h3><p dir="ltr">We show that our network differencing procedure can effectively and efficiently detect statistical significant network re-wirings in different conditions. …”
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Prediction of the Backwater Level Due to Bridge Constriction in Waterways
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Investigating energy savings due to implementing green roof on existing residential buildings in UAE
Published 2013“…In recent years, building energy consumption keeps rising due to growth in population, increasing demand for comfort in indoor environment and global climate changing. …”
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
Published 2025“…Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…”
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Safety experiments for small robots investigating the potential of soft materials in mitigating the harm to the head due to impacts
Published 2019“…<p>There is a growing interest in social robots to be considered in the therapy of children with autism due to their effectiveness in improving the outcomes. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …”
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Unveiling the effect of shapes and electrolytes on the electrocatalytic ethanol oxidation activity of self-standing Pd nanostructures
Published 2023“…Morphologically controlled Pd-based nanocrystals are the most efficient strategies for improving the electrocatalytic ethanol oxidation reaction (EOR) performance; however, their morphological-EOR activity relationship and effect of electrolytes at a wide pH range are still ambiguous. …”
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TCAD Simulation and Analysis of Selective Buried Oxide MOSFET Dynamic Power
Published 2019“…Increasing power dissipation may lead to decreasing system effciency and lifetime. The BULK metal oxide semiconductor field-effect transistor (MOSFET) has relatively high power dissipation and low frequency response due to its internal capacitances. …”
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