Detection of statistically significant network changes in complex biological networks by Raghvendra Mall (581171)

“…<h3>Background</h3><p dir="ltr">Biological networks contribute effectively to unveil the complex structure of molecular interactions and to discover driver genes especially in cancer context. …”

The combinatory effects of diet and exercise on BDNF gene expression by Bassil, Maya

“…Results showed that supplementation with 1.5% leucine significantly induced BDNF in the brain, and this effect was additive with exercise as well. …”
Get full text
Get full text
Get full text

Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion by Khoury, Nathalie

“…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…”
Get full text
Get full text
Get full text

Investigation of the Effect of Imatinib and Hydroxyurea Combination Therapy on Hematological Parameters and Gene Expression in Chronic Myeloid Leukemia (CML) Patients by Esraa K. Al-Amleh (16023071)

“…The primary goal of this study is to compare the effects of single and Imatinib (IM) and Hydroxyurea (HU) combined treatment on hematological parameters and gene expression in CML patients.…”

Impact of inflammation, gene variants, and cigarette smoking on coronary artery disease risk by Merhi, Mahmoud

“…Moreover, it also shows the effect of smoking-gene interaction on CAD risk, where the CYP1A1 MspI polymorphism revealed a decreased risk in current smokers.…”
Get full text
Get full text
Get full text

Gene-specific machine learning model to predict the pathogenicity of BRCA2 variants by Mohannad N. Khandakji (13885434)

“…<h3>Background</h3><p dir="ltr">Existing BRCA2-specific variant pathogenicity prediction algorithms focus on the prediction of the functional impact of a subtype of variants alone. General variant effect predictors are applicable to all subtypes, but are trained on putative benign and pathogenic variants and do not account for gene-specific information, such as hotspots of pathogenic variants. …”

Accelerating Sepsis Diagnosis Through Culture-Free Genomics: Early Findings And Cost-Effectiveness From A Pilot Study by Faisal E. Ibrahim (19962788)

Organic micropollutants in aerobic and anaerobic membrane bioreactors: Changes in microbial communities and gene expression by Harb, Moustapha

“…Results showed that presence of OMPs in the wastewater feed had a clear effect on keystone bacterial populations in both the aerobic and anaerobic sludge while also significantly impacting biodegradation-associated gene expression levels. …”
Get full text
Get full text
Get full text
Get full text

Analysis of Resistance to Antimicrobials and Presence of Virulence/Stress Response Genes in Campylobacter Isolates from Patients with Severe Diarrhoea by Haitham Ghunaim (703817)

Effects of paternal and chronological age on BEGAIN methylation and its possible role in autism by Ramya Potabattula (4401160)

“…There was no comparable maternal age effect on FCB methylation. In addition, we found a significant negative correlation between <i>BEGAIN</i> methylation and chronological age (ranging from 1 to 70 years) in peripheral blood samples of male but not of female donors. …”

Ethnic-specific association of amylase gene copy number with adiposity traits in a large Middle Eastern biobank by Niccolo’ Rossi (14152692)

“…Here, we leverage population size and detailed adiposity measures from a large population biobank to resolve confounding effects and determine the relationship between salivary (AMY1) and pancreatic (AMY2A) amylase genes CN and adiposity in 2935 Qatari individuals who underwent whole-genome sequencing (WGS) as part of the Qatar Genome Programme. …”

The Paget's disease of bone risk gene <i>PML</i> is a negative regulator of osteoclast differentiation and bone resorption by Sachin Wani (11704868)

“…Furthermore, the inhibitory effect of IFN-γ on osteoclast formation from Pml−/− was significantly blunted compared with wild type. …”

Associations between telomere attrition, genetic variants in telomere maintenance genes, and non-small cell lung cancer risk in the Jammu and Kashmir population of North India by Gh. Rasool Bhat (6701726)

“…</p><h3>Methods</h3><p dir="ltr">We employed the cost-effective and high-throughput MassARRAY MALDI-TOF platform to assess the genetic associations of select variants within telomere maintenance genes in a population from Jammu and Kashmir, North India. …”

Toxicity assessment of di(2-ethylhexyl) phthalate using zebrafish embryos: Cardiotoxic potential by Azza, Naïja

“…Phthalate plasticizers including the Di-2-ethylhexyl phthalates (DEHP) are toxic and induce adverse effects on the different organization levels of the environment. …”
Get full text
Get full text
Get full text

Detection Of heterozygous large deletions in the antithrombin gene using multiplex polymerase chain reaction and denatured high performance liquid chromatography by El Maarri, O.

“…The present study reports a method for the easy, rapid and cost effective detection of heterozygous large deletions. …”
Get full text
Get full text
Get full text

Identification of a Gene Panel Predictive of Triple-Negative Breast Cancer Response to Neoadjuvant Chemotherapy Employing Transcriptomic and Functional Validation by Radhakrishnan Vishnubalaji (3563306)

“…Mechanistically, targeted depletion of the eight genes reduced the proliferation potential of TNBC cell models, while most remarkable effects were for combined SLC39A7, TIMM13, BANF1, and MVD knockdown in conjunction with doxorubicin. …”

iPSC-Derived Pancreatic Progenitors Lacking FOXA2 Reveal Alterations in miRNA Expression Targeting Key Pancreatic Genes by Noura Aldous (15429873)

“…RNA sequencing analysis demonstrated significant reduction in the mRNA expression of genes involved in the development and function of exocrine and endocrine pancreas. …”

Long non-coding RNA MALAT1 promotes steatosis in HepG2 cells by modulating target gene expression in presence of Exendin-4 by Olfa Khalifa (10914452)

“…</p> <p>Results: Treatment with 200nM Ex-4 for 3h decreased the OA-induced lipid buildup significantly (p<0.05). Concurrently, Ex-4 significantly lowered the expression levels of De novo lipogenesis genes such as SREBP-1, SCD-1and ACC. …”

Sestrin2 as a Novel Biomarker and Therapeutic Target for Various Diseases by Mazhar Pasha (11197767)

“…Sestrin2 also plays a pivotal role in metabolic regulation through activation of the key energy sensor AMP-dependent protein kinase (AMPK) and inhibition of mammalian target of rapamycin complex 1 (mTORC1). Other downstream effects of Sestrins include autophagy activation, antiapoptotic effects in normal cells, and proapoptotic effects in cancer cells. …”

Genome-Wide Association Study Reveals a Novel Association Between MYBPC3 Gene Polymorphism, Endurance Athlete Status, Aerobic Capacity and Steroid Metabolism by Fatima Al-Khelaifi (4741026)

“…</p><h3>Conclusions</h3><p dir="ltr">This is the first report of genome-wide significant SNP and related metabolites associated with elite athlete status. …”