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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Accessibility of large events: an empirical study of the Expo 2020 Dubai
Published 2024“…The objective of this paper is to contribute to understanding the accessibility of large events in an increasingly technology-dependent industry. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…This is specifically relevant in designing assays that require bioluminescence for extended periods, such as in the case of biosensors designed for monitoring slow enzymatic or <u>cellular signaling</u> reactions, without necessitating multiple rounds of luciferase substrate addition or any specialized reagents that result in increased assay costs. In the current manuscript, we report a mutant NLuc that possesses a stable and prolonged bioluminescence activity, albeit lower than the wild-type NLuc, and envisage a wider application of the mutant NLuc in designing biosensors for monitoring slower biological and biomedical events.…”
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The Impact of a Computerized Potassium Alert on Adverse Drug Events and Pharmacists' Interventions
Published 2010“…Conclusions: Implementation of a computerized pharmacy alert resulted in a statistically significant decrease in adverse drug events related to hyperkalemia in our institution. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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The Influence of Risks on the Success of the Development and Installation of Temporary Structure in Event Projects in Dubai
Published 2017“…The number of events in Dubai is getting increased and the temporary structures have been widely used as a mandatory element to support the event’s venue whether to expand the capability of the venue or to create the ambience for the event. …”
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Keyed Watermarks: A Fine-grained Tracking of Event-time in Apache Flink
Published 2023“…A significant part of this process is played by watermarks, which are unique timestamps that show the passage of events in time. …”
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Knowledge-based virtual outdoor weather event simulator using unity 3D
Published 2022“…During the past two decades, 3D simulation models have gained importance in the development of software solutions that aim to mimic real-world events and phenomena with increasing levels of accuracy and detail. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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Retrospective identification of medication related adverse events in the emergency medical services through the analysis of a patient safety register
Published 2022“…Prehospital medication related adverse events remain a significant threat to patient safety in this setting and warrant greater widespread attention and future identification of strategies aimed at their reduction.…”
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The effect of self-reported flossing behavior on cardiovascular disease events and mortality Findings from the 2009-2016 National Health and Nutrition Examination Surveys
Published 2025“…ConclusionsPoor flossing behavior is associated with higher prevalence of cardiovascular events, increased risk of experiencing CVD mortality, and elevated CRP levels. …”
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Rapid climate changes and human dynamics during the holocene in the eastern mediterranean (Lower Strymon Valley, northern Greece)
Published 2023“…This sedimentary record represents a significant opportunity for high-resolution palaeoenvironmental studies of the period from 6 to 3 ka cal BP linked to land use and climate change. …”
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How circular economy can reduce scope 3 carbon footprints: Lessons learned from FIFA world cup Qatar 2022
Published 2023“…However, such events also leave significant negative impacts on the environment such as an increase in greenhouse gas (GHG) emissions in the host and neighboring countries. …”
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