Cardiac phosphodiesterases are differentially increased in diabetic cardiomyopathy by Hanna, Rita

“…Upregulation of β1-AR receptor transcripts was noted in diabetic hearts at 4 weeks along with an increase in cAMP levels and an upregulation in the ejection fraction and fraction shortening. …”
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L1-CAM knock-down radiosensitizes neuroblastoma IMR-32 cells by simultaneously decreasing MycN, but increasing PTEN protein expression by Rached, Johnny

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Both decreasing interstructural space size and increasing total cover increase shrimp abundance on artificial structures deployed in a UAE seagrass bed by Bartholomew, Aaron

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Performance and microbial community variations of anaerobic digesters under increasing tetracycline concentrations by Xiong, Yanghui

“…An increase in the abundance of tetracycline resistance genes associated with ribosomal protection proteins was observed after 30 days of exposure to high concentrations of tetracycline, while other targeted resistance genes showed no significant changes. …”
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Addition of sphingosine-1-phosphate to human oocyte culture medium decreases embryo fragmentation by Zreik, Tony

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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion by Khoury, Nathalie

“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Exendin-4 promotes GSIS without increasing β-cell number through upregulation of glucose-sensing apparatus and mitochondrial oxidative phosphorylation machinery genes in hPSC-deriv... by Abdoulaye Diane (14152749)

“…Interestingly, addition of Exendin-4 (50 nM) during the last 3 days of the differentiation significantly enhanced GSIS associated with increased expression of glucose-sensing apparatus genes (Glut2, G6P2C, GCK) and genes encoding mitochondrial oxidative phosphorylation machinery.…”

Targeted Inactivation of Rin3 Increases Trabecular Bone Mass by Reducing Bone Resorption and Favouring Bone Formation by Mahéva Vallet (18456729)

“…</p><p dir="ltr">Correction: Targeted Inactivation of <i>Rin3</i> Increases Trabecular Bone Mass by Reducing Bone Resorption and Favouring Bone Formation <a href="https://doi.org/10.1007/s00223-021-00849-w" target="_blank">https://doi.org/10.1007/s00223-021-00849-w</a>, published online 19 April 2021.…”

Serum Vitamin D Concentration ≥75 nmol/L Is Related to Decreased Cardiometabolic and Inflammatory Biomarkers, Metabolic Syndrome, and Diabetes; and Increased Cardiorespiratory Fitn... by Vijay Ganji (8710491)

The Paget's disease of bone risk gene <i>PML</i> is a negative regulator of osteoclast differentiation and bone resorption by Sachin Wani (11704868)

“…<p dir="ltr">Paget's disease of bone (PDB) is characterized by focal increases in bone remodelling. Genome-wide association studies identified a susceptibility locus for PDB tagged by rs5742915, which is located within the PML gene. …”

Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex by Wesam S. Ahmed (10170053)

“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”

Loss of FOXA2 induces ER stress and hepatic steatosis and alters developmental gene expression in human iPSC-derived hepatocytes by Maryam Aghadi (17128819)

“…Lack of FOXA2 resulted in significant alterations in the expression of key developmental and functional genes in hepatic progenitors (HP) and mature hepatocytes (MH) as well as an increase in the expression of ER stress markers. …”

Transcriptome analysis of Escherichia coli K1 after therapy with hesperidin conjugated with silver nanoparticles by Masri, Abdulkader

“…Of note, the expression levels of cation efflux genes (cusA and copA) and translocation of ions, across the membrane genes (rsxB) were found to increase 2.6, 3.1, and 3.3- log FC, respectively. …”
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Photoactivatable RuII Complex Bearing 2,9‐Diphenyl‐1,10‐phenanthroline: Unusual Photochemistry and Significant Potency on Cisplatin‐Resistant Cell Lines by Mansour, Najwa

“…Complex 1 demonstrated only marginal activity in the dark; its cytotoxicity increased significantly upon photoactivation with a high phototoxicity index (PI = [IC50 dark]/[IC50 light]) ranging from 39.2‐fold in A549 to over 100‐fold in MDA‐MB‐231. …”
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Long non-coding RNA MALAT1 promotes steatosis in HepG2 cells by modulating target gene expression in presence of Exendin-4 by Olfa Khalifa (10914452)

“…Concurrently, Ex-4 significantly lowered the expression levels of De novo lipogenesis genes such as SREBP-1, SCD-1and ACC. …”

Significance of Avicennia Marina in the Arabian Gulf Environment: A Review by Kaiprath Puthiyapurayil Haseeba (21392966)

“…<p dir="ltr">Mangroves are ecologically important and highly productive intertidal plants that thrive in saline to brackish environments in tropical and subtropical shallow-water habitats. <i>Avicennia marina</i> is the only mangrove species found in the Arabian Gulf (hereafter the ‘Gulf’) coastal region, marking the northernmost boundary of mangroves in the Indo-Pacific region. …”

HbA1c over 8.5% is not predictive of increased infection rate following penile prosthesis implant surgery in diabetic patients with erectile dysfunction by Raidh Talib (14779198)

“…A comparison between diabetic patients with penile prosthesis implantation infection and those without infection revealed no significant difference in the level of haemoglobinA1c between the two groups with mean haemoglobinA1c in patients with infected implants 7.14 and 7.59 for noninfected (<i>p</i> = 0.491). …”

Significance of microscopically incomplete resection margin after esophagectomy for esophageal cancer by Markar, Sheraz R.

“…There were significant differences between the groups in postoperative histology, with an increase in pathological stage III and TRG 4–5 in the R1 group. …”
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Exploring the evolution of <i>Acinetobacter baumannii</i> and <i>Pseudomonas aeruginosa</i> resistance during the COVID-19 era by Emine Sehmen (22457614)

“…</p><h3>Results</h3><p dir="ltr">The average age of the patients was 61.3 ± 21.9 years (range: 18–95), with a majority of 1306 (51.6%) being male. During the pandemic, <i>A. baumannii</i> isolates showed a significant increase in resistance rates for several antibiotics compared to the pre-pandemic period: imipenem (96% vs 35.1%), amikacin (84.1% vs 14.4%), ciprofloxacin (96.9% vs 36.9%), trimethoprim-sulfamethoxazole (66.4% vs 27%), and ceftazidime (96.5% vs 33.3%) (all with <i>P</i>< .001). …”

Iron-related dietary pattern increases the risk of poor cognition by Zumin Shi (287671)