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Genome-Based Characterization of Bacterial Pathogens Causing Bloodstream Infection
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2
Willingness to participate in genome testing: a survey of public attitudes from Qatar
Published 2020“…The success of a national population-based genome program, like the Qatar Genome Program (QGP), depends on the willingness of citizens to donate samples and take up genomic testing services. …”
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The Prevalence and Genetic Spectrum of Familial Hypercholesterolemia in Qatar Based on Whole Genome Sequencing of 14,000 Subjects
Published 2022“…This pioneering study provides a reliable estimate of FH prevalence in Qatar based on a significantly large population-based cohort, whilst uncovering the spectrum of genetic variants associated with FH.…”
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Whole-genome sequencing based molecular characterization of multi-drug resistant isolates of Enterobacter spp. and Klebsiella aerogenes in Lebanon. (c2019)
Published 2019“…Results were further confirmed through complimentary PCR assays and plasmid-based replicon typing (PBRT). Phylogenetic relatedness was assessed through whole-genome average nucleotide identity (wgANI) and core-genome single nucleotide polymorphism (cgSNP) based phylogenetic analysis. …”
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6
Whole-genome Sequences of Multidrug-Resistant Escherichia coli
Published 2023“…Genome comparison, multilocus sequence typing (MLST), and whole-genome SNP-based phylogenetic analysis (wgSNP) were used to determine the relatedness of the isolates. …”
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7
Distinct genomic features across cytolytic subgroups in skin melanoma
Published 2022“…Mutational signatures and kataegis were explored using SigProfiler and compared to the known single or doublet base substitution signatures from COSMIC.</p> <h2>Results</h2> <p>Metastatic skin melanomas had significantly higher CYT levels compared to primary tumors. …”
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Genomic architecture of autism spectrum disorder in Qatar: The BARAKA-Qatar Study
Published 2023“…Moreover, it uncovers a significant role for recessive variation in ASD architecture in consanguineous settings and provides a unique resource of Middle Eastern genomes for future research to the global ASD community.…”
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Whole-Genome Sequence Analysis of Carbapenem-Resistant Enterobacteriaceae Recovered from Hospitalized Patients in Lebanon
Published 2020“…It was also the largest genome-based study in the region, revealing the tremendous heterogeneity, plasmid content, and various resistance determinants circulating in the country. …”
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10
Comprehensive whole genome sequence analyses yields novel genetic and structural insights for Intellectual Disability
Published 2017“…The <i>de novo</i> assembly resulted in unmasking hidden genome instability that was missed by standard re-alignment based algorithms. …”
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Natural resource dependence and war nexus: new insights
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Antibiotic Resistance, Virulence Factors and Whole-Genome Characterization of Enterobacter spp. and Klebsiella aerogenes isolated from hospitals in Lebanon
Published 2022“…This study presents a comprehensive whole-genome-based characterization of multidrug resistant and hypervirulent ECC members recovered from clinical settings in Lebanon. …”
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13
Accelerating Sepsis Diagnosis Through Culture-Free Genomics: Early Findings And Cost-Effectiveness From A Pilot Study
Published 2025“…</p><h3 dir="ltr">Conclusion</h3><p dir="ltr">ONT-based 16S rRNA sequencing offers a rapid, sensitive, and cost-effective alternative to traditional blood cultures for diagnosing neonatal sepsis, with the potential to significantly improve clinical outcomes in NICU settings.…”
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Genome-wide association study and trans-ethnic meta-analysis identify novel susceptibility loci for type 2 diabetes mellitus
Published 2024“…</p><h3>Methods</h3><p dir="ltr">Using whole genome sequencing of 11,436 participants (2765 T2D cases and 8671 controls) from the population-based Qatar Biobank (QBB), we conducted a genome-wide association study (GWAS) of T2D with and without body mass index (BMI) adjustment.…”
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Genetic Basis and Prognostic Value of Exercise QT Dynamics
Published 2020“…Genome-wide association studies were conducted to identify genetic variants and bioinformatics analyses were performed to prioritize candidate genes. …”
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When Should a Brain MRI Be Performed in Children with New-Onset Seizures? Results of a Large Prospective Trial
Published 2021“…Univariate analysis showed a significant increase in the frequency of epileptogenic lesions with decreasing age, the presence of developmental delay, and the number and types of seizures at presentation. …”
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Fourier-Transform Infrared Imaging Spectroscopy and Laser Ablation -ICPMS New Vistas for Biochemical Analyses of Ischemic Stroke in Rat Brain
Published 2018“…</p><p dir="ltr"><br></p><h3>Results</h3><p dir="ltr">The FTIR results revealed that in the lesioned gray matter the relative distribution of lipid, lipid acyl and protein contents decreased significantly. Also at this locus, there was a significant increase in aggregated protein as detected by high-levels Aβ1-42. …”
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QPGx‐CARES: Qatar pharmacogenetics clinical applications and research enhancement strategies
Published 2024“…<p dir="ltr">Pharmacogenetic (PGx)‐informed medication prescription is a cutting‐edge genomic application in contemporary medicine, offering the potential to overcome the conventional “trial‐and‐error” approach in drug prescription. …”
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A population study of clinically actionable genetic variation affecting drug response from the Middle East
Published 2022“…We analyzed 6,045 whole genomes from the Qatari population for the distribution of allele frequencies of 2,629 variants in 1,026 genes known to affect 559 drugs or classes of drugs. …”
