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Genome-Based Characterization of Bacterial Pathogens Causing Bloodstream Infection
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Willingness to participate in genome testing: a survey of public attitudes from Qatar
Published 2020“…The success of a national population-based genome program, like the Qatar Genome Program (QGP), depends on the willingness of citizens to donate samples and take up genomic testing services. …”
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The Prevalence and Genetic Spectrum of Familial Hypercholesterolemia in Qatar Based on Whole Genome Sequencing of 14,000 Subjects
Published 2022“…This pioneering study provides a reliable estimate of FH prevalence in Qatar based on a significantly large population-based cohort, whilst uncovering the spectrum of genetic variants associated with FH.…”
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Hedonic valuation of land protection methods: implications for cluster development.
Published 2014“…The key findings of the study are: (i) proximity to national or state park land and to city or county open space has a significant positive impact on property values, while proximity to national forest land or to privately conserved land exhibits no significant effects; and, (ii) inclusion of a property within a cluster development decreases its value by 17 to 26 %. …”
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Whole-genome sequencing based molecular characterization of multi-drug resistant isolates of Enterobacter spp. and Klebsiella aerogenes in Lebanon. (c2019)
Published 2019“…Results were further confirmed through complimentary PCR assays and plasmid-based replicon typing (PBRT). Phylogenetic relatedness was assessed through whole-genome average nucleotide identity (wgANI) and core-genome single nucleotide polymorphism (cgSNP) based phylogenetic analysis. …”
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masterThesis -
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Whole-genome Sequences of Multidrug-Resistant Escherichia coli
Published 2023“…Genome comparison, multilocus sequence typing (MLST), and whole-genome SNP-based phylogenetic analysis (wgSNP) were used to determine the relatedness of the isolates. …”
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Distinct genomic features across cytolytic subgroups in skin melanoma
Published 2022“…Mutational signatures and kataegis were explored using SigProfiler and compared to the known single or doublet base substitution signatures from COSMIC.</p> <h2>Results</h2> <p>Metastatic skin melanomas had significantly higher CYT levels compared to primary tumors. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Further, analysis of trajectories for <u>hydrogen bonds</u> (H-bonds) formed between NLuc and furimazine revealed substantial H-bond interaction between R162 and Q32 residues. …”
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Genomic architecture of autism spectrum disorder in Qatar: The BARAKA-Qatar Study
Published 2023“…Moreover, it uncovers a significant role for recessive variation in ASD architecture in consanguineous settings and provides a unique resource of Middle Eastern genomes for future research to the global ASD community.…”
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Whole-Genome Sequence Analysis of Carbapenem-Resistant Enterobacteriaceae Recovered from Hospitalized Patients in Lebanon
Published 2020“…It was also the largest genome-based study in the region, revealing the tremendous heterogeneity, plasmid content, and various resistance determinants circulating in the country. …”
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Comprehensive whole genome sequence analyses yields novel genetic and structural insights for Intellectual Disability
Published 2017“…The <i>de novo</i> assembly resulted in unmasking hidden genome instability that was missed by standard re-alignment based algorithms. …”
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Antibiotic Resistance, Virulence Factors and Whole-Genome Characterization of Enterobacter spp. and Klebsiella aerogenes isolated from hospitals in Lebanon
Published 2022“…This study presents a comprehensive whole-genome-based characterization of multidrug resistant and hypervirulent ECC members recovered from clinical settings in Lebanon. …”
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Accelerating Sepsis Diagnosis Through Culture-Free Genomics: Early Findings And Cost-Effectiveness From A Pilot Study
Published 2025“…</p><h3 dir="ltr">Conclusion</h3><p dir="ltr">ONT-based 16S rRNA sequencing offers a rapid, sensitive, and cost-effective alternative to traditional blood cultures for diagnosing neonatal sepsis, with the potential to significantly improve clinical outcomes in NICU settings.…”
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Genome-wide association study and trans-ethnic meta-analysis identify novel susceptibility loci for type 2 diabetes mellitus
Published 2024“…</p><h3>Methods</h3><p dir="ltr">Using whole genome sequencing of 11,436 participants (2765 T2D cases and 8671 controls) from the population-based Qatar Biobank (QBB), we conducted a genome-wide association study (GWAS) of T2D with and without body mass index (BMI) adjustment.…”
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Spatial, temporal, and demographic patterns in prevalence of chewing tobacco use in 204 countries and territories, 1990–2019: a systematic analysis from the Global Burden of Diseas...
Published 2021“…Among females, none of these 12 countries had significant decreases in prevalence of chewing tobacco use, whereas seven of 12 countries had a significant decrease in the prevalence of tobacco smoking use for the period. …”
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Mapping subnational HIV mortality in six Latin American countries with incomplete vital registration systems
Published 2021“…</p><h3>Conclusions</h3><p dir="ltr">Our subnational estimates of HIV mortality revealed significant spatial variation and diverging local trends in HIV mortality over time and by age. …”
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Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990–2019: a systematic analysis...
Published 2021“…Although prevalence of smoking had decreased significantly since 1990 among both males (27·5% [26·5–28·5] reduction) and females (37·7% [35·4–39·9] reduction) aged 15 years and older, population growth has led to a significant increase in the total number of smokers from 0·99 billion (0·98–1·00) in 1990. …”
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Genetic Basis and Prognostic Value of Exercise QT Dynamics
Published 2020“…Genome-wide association studies were conducted to identify genetic variants and bioinformatics analyses were performed to prioritize candidate genes. …”
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