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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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The Association of Hypertension with Increased Mortality Rate During the COVID-19 Pandemic: An Update with Meta-analysis
Published 2023“…In addition, a combination of other comorbidities and old age appears to increase the risk of mortality from COVID-19.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Epidemiology and Global Health<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s44197-023-00130-3" target="_blank">https://dx.doi.org/10.1007/s44197-023-00130-3</a></p>…”
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Mapping subnational HIV mortality in six Latin American countries with incomplete vital registration systems
Published 2021“…<h3>Background</h3><p dir="ltr">Human immunodeficiency virus (HIV) remains a public health priority in Latin America. While the burden of HIV is historically concentrated in urban areas and high-risk groups, subnational estimates that cover multiple countries and years are missing. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…In this regard, engineering of brighter bioluminescent proteins, i.e. luciferases, has played a significant role. This is acutely exemplified by the engineering of the NLuc <u>luciferase</u>, which is small in size and displays much enhanced bioluminescence and<u> thermal stability</u> compared to previously available luciferases. …”
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Challenges in child and adolescent health across the Arab Gulf countries—Focus on metabolic health
Published 2025“…The combination of an increasing youth population combined with rapid modernisation, increasing per capita income and the paradigm shift towards unhealthy and affluent lifestyles has created a significant burden of non‐communicable diseases (NCDs), especially obesity and diabetes. …”
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The Relationship between Smoking Cessation and Health Insurance Coverage: An Analysis of Cost Saving and Health Outcomes
Published 2023“…The findings have important implications for policymakers and health insurers in promoting healthy behaviors and increasing access to smoking cessation programs that could have significant benefits for both individuals and society.…”
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Small molecule inhibition of stat3 enhances survival in mice with intracerebral melanoma
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Project Productivity vs. Health & Safety
Published 2008“…It was found in both cases that the improved safety management approaches had a great effect on the workforce both in improving accident reporting statistics matched by significant gains in productivity. The outcome of the surveys also supported this showing great increase in the perception of safety in the work place and increased levels of motivation and good feeling towards the management of each Company. …”
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Osteoporosis: An under-recognized public health problem
Published 2016“…Importantly, osteoporosis and resulting bone fractures represent a significant economic burden for both individuals and the wider society. …”
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Suppression of Unstable Flow by Using Rough Surfaces at Small Mass Flow Rates in a Radial Diffuser
Published 2006Get full text
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Evaluating the impact of a brief Health at Every Size-informed health promotion activity on body positivity and internalized weight-based oppression
Published 2021“…Body acceptance and appreciation increased significantly after the activity. Qualitative results suggest that these improvements were sustained at follow up. …”
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Maternal microbiota and gestational diabetes: impact on infant health
Published 2023“…Pregnancy is accompanied by tightly regulated changes in the endocrine, metabolic, immune, and microbial systems, and deviations from these changes can alter the mother’s metabolism resulting in adverse pregnancy outcomes and a negative impact on the health of her infant. Maternal microbiomes are significant drivers of mother and child health outcomes, and many microbial metabolites are likely to influence the host health. …”
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The association between mental health well-being and risky behaviors among adolescents in Argentina: Data from the 2018 global school health survey
Published 2025“…</p><h3>Results</h3><p dir="ltr">Poor mental health well-being was associated with an increase in odds of engaging in risky behaviors. …”