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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Significance of Avicennia Marina in the Arabian Gulf Environment: A Review
Published 2025“…However, in the past two decades Gulf mangroves have been facing significant threats, including extensive coastal development, shoreline modification by establishing marinas and ports, and climate change-associated impacts such as sea-level rise and altered precipitation patterns, which pose significant risks to this fragile ecosystem. …”
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Facilitating and hindering factors for coping with the experience of having a child with cancer
Published 2017“…This condition is reported to evoke a range of challenging emotions for parents, yet no studies have been conducted on the facilitating and hindering factors that affect Lebanese parents coping with a child with cancer. …”
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Exploring the Significance of Publication-Age-Based Parameters for Evaluating Researcher Impact
Published 2023“…In addition, these indices are often evaluated using dissimilar datasets, making it challenging to accurately compare their contributions and significance. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Enhancing Arabic Reading Proficiency as a Second Language: Unveiling the Significance of Audiobooks for Middle School Students
Published 2024“…Considering audiobooks as a useful tool in improving reading skills and language acquisition, this study aims to explore the potential benefits and effectiveness of using audiobooks as a tool for learning for non-Arab students in Dubai, as there is a diverse student population including individuals from various cultural and linguistic backgrounds which can present significant challenges. It also discusses the pedagogical philosophy of how teachers and students use this tool, identifies the obstacles to the appropriate use of audiobooks in Middle Schools in Dubai, and lastly, make suggestions about how to get through these obstacles. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Novice Teachers’ Challenges and Induction Programs
Published 2023“…To promote novice teachers’ professional growth, participants have suggested significant recommendations to support early career teachers.…”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Oral Food Challenge Protocols in Food Protein-Induced Enterocolitis Syndrome: A Systematic Review
Published 2025“…</p><h3>Conclusions</h3><p dir="ltr">There is significant heterogeneity in <u>FPIES </u>OFC practices. …”
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The Challenges of Corporate Governance Systems for Construction Project Management
Published 2014“…However, despite the growth in the area, the industry continues to face different challenges. Researchers have associated the challenges with poor corporate governance. …”
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Deep Learning in LncRNAome: Contribution, Challenges, and Perspectives
Published 2020“…<p dir="ltr">Long non-coding RNAs (lncRNA), the pervasively transcribed part of the mammalian genome, have played a significant role in changing our protein-centric view of genomes. …”
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Editorial: At the Crossroads: Lessons and Challenges in Computational Social Science
Published 2016“…At the turn of the century, however, it was clear that huge challenges—and new opportunities— lied ahead: the digital communication technologies, and their associated data deluge, began to nurture those models with empirical significance. …”
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An investigation into the impact of COVID-19 on school leadership in Dubai
Published 2022“…In an attempt to gain an insight into their experiences, the aim of this small-scale research project was to explore the challenges that principals have encountered during the COVID-19 pandemic and the solutions they made to overcome these challenges. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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