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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Exploring the Significance of Publication-Age-Based Parameters for Evaluating Researcher Impact
Published 2023“…In addition, these indices are often evaluated using dissimilar datasets, making it challenging to accurately compare their contributions and significance. …”
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Trade‐Offs Among SDGs: How the Pursuit of Economic, Food, and Urban Development Goals May Undermine Climate and Equity Targets?
Published 2025“…Employing a review‐based approach to assess SDG interactions—focusing on the climate‐development nexus, particularly the relationship between economic expansion (SDG 8), environmental sustainability (SDGs 13–15), and social equity (SDGs 1, 5, and 10)—this research identifies key areas of conflict that challenge the framework's internal coherence. Findings indicate significant trade‐offs between economic growth and environmental sustainability, alongside previously underexamined tensions between social equity goals and resource‐intensive development strategies. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Enhancing Arabic Reading Proficiency as a Second Language: Unveiling the Significance of Audiobooks for Middle School Students
Published 2024“…Considering audiobooks as a useful tool in improving reading skills and language acquisition, this study aims to explore the potential benefits and effectiveness of using audiobooks as a tool for learning for non-Arab students in Dubai, as there is a diverse student population including individuals from various cultural and linguistic backgrounds which can present significant challenges. It also discusses the pedagogical philosophy of how teachers and students use this tool, identifies the obstacles to the appropriate use of audiobooks in Middle Schools in Dubai, and lastly, make suggestions about how to get through these obstacles. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Staff attributions about the causes of challenging behaviours
Published 2002“…Significantly more staff attributed challenging behaviour to negative reinforcement and self-stimulation after training. …”
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Race/ethnicity and challenges for optimal insulin therapy
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Oral Food Challenge Protocols in Food Protein-Induced Enterocolitis Syndrome: A Systematic Review
Published 2025“…</p><h3>Conclusions</h3><p dir="ltr">There is significant heterogeneity in <u>FPIES </u>OFC practices. …”
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Intensive English Students Communication Skills: Challenges and Solutions
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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Feeder protection challenges with high penetration of inverter based distributed generation
Published 2013“…The increasing proportion of inverter based distributed generation (DG) in the power system may limit the short circuit power available at distribution substations and consequently cause significant troubles for the protection of distribution feeders where DG are connected. …”
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Risk Management Impact on the Legal Challenges of Fast-Track Projects in Dubai
Published 2018“…The study shows that poor implementation of the risk management in the fast-track could leads to divesting legal challenges which may affect the project execution. The aim is to establish and prove that effective risk management can reduce the number of legal challenges for successful construction project in the Dubai.…”
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Adoption of blockchain technology in healthcare systems: benefits, potential applications, and challenges
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Microalgal-based desalination brine remediation: Achievements, challenges, and future research trends
Published 2024“…In addition, desalination plants consume significant amounts of energy, which contribute to carbon emissions and global warming. …”
