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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Exploring Physical Education Teachers’ Intention and Perceived Constraints in Offering Online Lessons Using the Theory of Planned Behavior: A Multi-Country Analysis
Published 2024“…<div><p>Guided by the theory of planned behavior, this study aimed to determine the influence of Physical Education (PE) teachers’ attitudes, their perceived behavioral control, and the influence of subjective norms on their intention and constraints (intrapersonal, interpersonal, and structural) to offer a high-quality class based on best practices to deliver PE lessons online during the COVID-19 pandemic. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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Investigating Educators’ Perceptions of the Impact of STEM Project-Based Learning on 21st Century Skills
Published 2024“…The findings indicate that the 18 items play a significant role in the implementation and practices of STEM PBL to develop 21st century skills.Teachers identified several challenges, such as managing extensive curriculum content, time constraints, limited resources, and difficulties in interdisciplinary collaboration. …”
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A Unified Model-Based Framework for the Simplified Execution of Static and Dynamic Assertion-Based Verification
Published 2020“…In order to simplify its execution, various Model Based System Engineering approaches provide a higher abstraction layer. …”
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Employee Motivation and Job Satisfaction in Project-based Organization: The case of the UAE
Published 2011“…All the organization’s need to focus on employee satisfaction and keep the worker motivated. In case of project based organizations, the subject acquires greater significance as the projects have various constraints and require quality manpower and effort on the part of employees. …”
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Simulation Based Optimization of Logistics Decisions Under Horizontal Collaboration
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Reinforcement Learning Based EV Charging Management Systems–A Review
Published 2021“…Unlike other machine learning approaches, the RL technique is based on maximizing the cumulative reward. This article reviews the existing literature related to the RL-based framework, objectives, and architecture for the charging coordination strategies of electric vehicles in the power systems. …”
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Beyond vanilla: Improved autoencoder-based ensemble in-vehicle intrusion detection system
Published 2023“…Detecting attacks on the CAN bus, particularly masquerade attacks, presents significant challenges. It necessitates an intrusion detection system (IDS) that effectively utilizes both CAN ID and payload data to ensure thorough detection and protection against a wide range of attacks, all while operating within the constraints of limited computing resources. …”
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Decision Support Model for Optimal Design of Wind Technologies Based Techno–Economic Approach
Published 2021“…<p dir="ltr">This paper aims to propose a practical decision support model for the optimal design of future wind turbines based on available wind potential on the site of interest. …”
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Does problem‐based learning facilitate enactment of learner agency in undergraduate dental curricula? A Q study
Published 2022“…<h3>Introduction</h3><p dir="ltr">Addressing a literature gap on leaner agency in health profession education, this study explores students' perceptions on which aspects of a problem‐based learning (PBL) environment cradle their leaner agency enactment.…”
