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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Association between Healthy Lifestyle Index and Cognitive decline In Community- Dwelling Lebanese Older Adults
Published 2021“…Participants in the highest HLI category had a significantly lower prevalence of cognitive decline as demonstrated by RUDAS (p<0.0001) and IQCODE (p<0.0001), but not by 10/66DRG (p=0.069). …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Untargeted Metabolomic Profiling Reveals Differentially Expressed Serum Metabolites and Pathways in Type 2 Diabetes Patients with and without Cognitive Decline: A Cross-Sectional S...
Published 2024“…We aimed to identify the metabolic pathways altered in diabetes-associated cognitive decline (DACD) using untargeted metabolomics. We conducted liquid chromatography–mass spectrometry-based untargeted metabolomics to profile serum metabolite levels in 100 patients with type 2 diabetes (T2D) (54 without and 46 with DACD). …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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The GCC Economies in the Wake of COVID-19: Toward Post-Oil Sustainable Knowledge-Based Economies?
Published 2022“…<p dir="ltr">The economic crisis and decline in oil prices caused by the pandemic led governments in the Gulf Cooperation Council (GCC) region to step up their diversification efforts. …”
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COVID-19 (SARS-CoV-2) outbreak monitoring using wastewater-based epidemiology in Qatar
Published 2021“…The estimated number of infected population on any given day using the wastewater-based epidemiology approach declined from 542,313 ± 51,159 to 31,181 ± 3081 over the course of the sampling period, which was significantly higher than the officially reported numbers. …”
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Deep learning-based modeling of land use/land cover changes impact on land surface temperature in Greater Amman Municipality, Jordan (1980–2030)
Published 2024“…The results of modeling LST showed an increase in average LST for all land cover types, with the most significant increases evident within urban areas and Rangelands/Sparsely vegetated areas. …”
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Drive‐up INR testing and phone‐based consultations service during COVID‐19 pandemic in a pharmacist‐lead anticoagulation clinic in Qatar: Monitoring, clinical, resource utilization...
Published 2023“…There was one reported bleeding and one emergency visit (0.9%) in the phone-based group vs none in the clinic-based group. Frequency of INR testing and compliance to attending clinics appointments declined significantly (<i>P</i> = .002; <i>P</i> = .001, respectively). …”
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The Grid Iron Patterns & Detached Villas as the Main Drivers of Sharjah City’s Urban Sprawl
Published 2021“…This rapid growth coincided with two phenomena worthy of attention, the first being the conjunction of this growth with the significant decline in residential density, and the second with the phenomenon of the increase in the proportion of non-durable residential lands, which reached 49% (DTPS, 1998) of the total land allocated to citizens. …”
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β-2-himachalen-6-ol protects against skin cancer development in vitro and in vivo
Published 2017“…A significant decrease in protein levels of p53 and Bcl-2 and a significant increase in p21 and Bax were observed. …”
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Initial risk assessment for pulmonary hypertension in patients with COPD
Published 2012“…Diffusion capacity was lower but did not reach statistical significance (P = 0.07). In multivariate analysis, statistically significant independent variables were >3% decrease in exercise oxyhemoglobin saturation and decline in prebronchodilator FEV1 (P = 0.01 and P = 0.04, respectively). …”
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Renewable Energy, Coal as a Baseload Power Source, and Greenhouse Gas Emissions: Evidence from U.S. State-Level Data
Published 2017“…It is estimated that a 10% increase in the share of renewable energy could decrease CH4 emissions by about 0.26%. …”
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