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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Evaluating the necessity of colonoscopy in patients under 40 with rectal bleeding: insights from a large-scale retrospective analysis
Published 2024“…The detection of significant lesions in this age group highlights the need for targeted colonoscopy based on specific risk factors such as family history and clinical presentation. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Risk factors for microscopic hematuria in women
Published 2016“…When stratifying the quantity of MH, women with increased red blood cells per high power field were more likely to have significant findings on their imaging results. …”
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Organizational factors that influence the success of IT projects
Published 2018“…The paper is focused on how the variables used per organizational factor is correlated with real-life scenarios and experiences of different project management teams that have been through project success and project failures. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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The Relationship between Lifestyle Factors and Obesity Indices among Adolescents in Qatar
Published 2019“…<h3>Background</h3><p dir="ltr">Physical inactivity, sedentary behaviour and an unhealthy diet are factors that may increase weight and general and/or abdominal obesity. …”
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Evaluating Microeconomic Factors, Financial Crisis, and Stock Price Dynamics: Evidence From MENA Region
Published 2020“…The results suggest that microeconomic fac tors play a vital role in determining stock prices in the MENA region. More specifically, factors such as return on equity, book value per share, dividend per share, earnings per share, and price-earnings ratio positively influence stock prices, while dividend yield and gearing have negative impact on stock prices. …”
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Evaluating Microeconomic Factors, Financial Crisis, and Stock Price Dynamics: Evidence From MENA Region
Published 2020“…The results suggest that microeconomic fac tors play a vital role in determining stock prices in the MENA region. More specifically, factors such as return on equity, book value per share, dividend per share, earnings per share, and price-earnings ratio positively influence stock prices, while dividend yield and gearing have negative impact on stock prices. …”
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Effects of information and communication technology on total-factor carbon emission efficiency and the health co-benefits
Published 2024“…The results suggest that ICT significantly and positively impacts the TFCEE. Specifically, for every 10 per cent increase in the internet development index, the TFCEE increases by 0.11 per cent. …”
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Prevalence and risk factors of poor indoor air quality and sick house syndrome symptoms in Dubai
Published 2019“…Notably that no significant association was found between any of the three HVAC systems studied by this research with SHS symptoms as per the adjusted MLR models. • Dimness with all SHS symptoms. • Stuffy air, dust, dirt, paint odors, dampness odors, in addition to attached kitchen with Eye, Nose, Throat, and Chest symptoms. • High humidity, incense smoke, water leakage, in addition to Dubai Sector 1 with General, Ergonomic, Nervous, and Skin symptoms. …”
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Cryptosporidium spp., prevalence, molecular characterisation and socio-demographic risk factors among immigrants in Qatar
Published 2019“…Conclusions/Significance Our results contribute to a better understanding of the epidemiology of cryptosporidiosis and the risk factors associated with the likelihood of carrying this infection among immigrant workers from developing countries.…”
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Dual-labeled trastuzumab-based imaging agent for the detection of human epidermal growth factor receptor 2 overexpression in breast cancer
Published 2007“…Nonspecific uptake in the SKBr3-luc tumors was analyzed by injecting the mice with IRDye 800CW and (111In-DTPA)p-IgG-(IRDye800)q, where “p” and “q” are the stoichiometric ratios of DTPA and IRDye 800CW bound per IgG antibody, respectively. Results: (DTPA)n-trastuzumab-(IRDye800)m showed significantly greater binding to SKBr3 cells than to MDA-MB-231 cells. …”
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Global, regional and national burden of bladder cancer and its attributable risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of...
Published 2021“…Bladder cancer accounted for 4.39 million (4.09 to 4.70) DALYs in 2019, and the age-standardised DALY rate decreased significantly by 18.6% (11.2 to 24.3) during the period 1990–2019. …”