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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Use of the portage curriculum to impact child and parent outcome in an early intervention program in Lebanon
Published 2020“…The results revealed significant differences in the participants’ pre and post ratings, indicating improvement in the children’s functional skills in all developmental areas. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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Changes in growth patterns due to nutritional adjustment in children of Northeast Brazil
Published 2014“…Body mass index increased throughout follow-up. Arm muscle area and tricipital skin fold increased significantly during the follow-up period.…”
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A Case Study of a Student with Visual Impairments in a Primary Government School in the United Arab Emirates
Published 2007“…The conclusions showed that there is a clear and significant need for provisions in different areas, including early intervention, training, and appropriate technology. …”
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Mapping subnational HIV mortality in six Latin American countries with incomplete vital registration systems
Published 2021“…</p><h3>Results</h3><p dir="ltr">All countries displayed over a 40-fold difference in HIV mortality between municipalities with the highest and lowest age-standardized HIV mortality rate in the last year of study for men, and over a 20-fold difference for women. Despite decreases in national HIV mortality in all countries—apart from Ecuador—across the period of study, we found broad variation in relative changes in HIV mortality at the municipality level and increasing relative inequality over time in all countries. …”
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Using Shockwave Lithotripsy to Treat Severe Calcified Mitral Stenosis in a Pregnant Woman
Published 2025“…<p dir="ltr">Rheumatic mitral stenosis (MS) with significant calcification presents challenges for both surgical and transcatheter interventions. …”
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β-2-himachalen-6-ol protects against skin cancer development in vitro and in vivo
Published 2017“…A significant decrease in protein levels of p53 and Bcl-2 and a significant increase in p21 and Bax were observed. …”
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An experimental study to measure the impact of a short-term disability awareness campaign on attitudes of primary school learners towards peers with physical disabilities
Published 2019“…Those with previous exposure scored better at the T0, but the non-exposed group benefitted the most from the intervention by scoring the most significant change at 2.15 units more than baseline. …”
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