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potentially » potential (Expand Search)
pathogenic » pathogens (Expand Search), pathogenesis (Expand Search)
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Prevalence of Blastocystis sp. and other gastrointestinal pathogens among diarrheic COVID-19 patients in Italy
Published 2024“…BackgroundGastrointestinal pathogens (GPs) contribute significantly to the burden of illness worldwide with diarrhoea being the most common among gastrointestinal symptoms (GSs). …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Metronidazole conjugated magnetic nanoparticles loaded with amphotericin B exhibited potent effects against pathogenic Acanthamoeba castellanii belonging to the T4 genotype
Published 2020“…Hence, the results obtained in this study have potential utility in drug development against infections caused by Acanthamoeba castellanii. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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Novel insights into the potential role of ion transport in sensory perception in Acanthamoeba
Published 2019“…Conclusions: The present study indicates that ion transporters are involved in sensory perception of A. castellanii suggesting their value as potential therapeutic targets to block cellular differentiation that presents a significant challenge in the successful prognosis of Acanthamoeba infections.…”
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Cutting‐edge technologies for detecting and controlling fish diseases: Current status, outlook, and challenges
Published 2024“…Therefore, this review aims to provide comprehensive information on the various aspects and challenges associated with modern technologies for controlling pathogenic microorganisms, as well as the potential benefits of using the IoT to improve fish health and welfare in aquaculture.…”
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Antifungal potential of plant-based extracts against <i>Candida</i> species: values, safety concerns, and possible applications
Published 2025“…<p dir="ltr">Fungal infections have emerged as a significant global health concern, with <i>Candida</i> species, opportunistic yeasts living symbiotically in various parts of the human body, playing a major role in pathogenic invasions. …”
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Computational identification of genetic subnetwork modules associated with maize defense response to Fusarium verticillioides
Published 2015“…We expect that the proposed analytic pipeline can also be adapted for investigating potential functional modules associated with host defense response in diverse plant-pathogen interactions.…”
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Vending machine buttons and touch screens
Published 2017“…Vending machine buttons or touch screenswere proved to act as vehicles of potential pathogens, unintentionally having a significant impact on the general health of the community. …”
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β-2-himachalen-6-ol protects against skin cancer development in vitro and in vivo
Published 2017“…A significant decrease in protein levels of p53 and Bcl-2 and a significant increase in p21 and Bax were observed. …”
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Genomic architecture of autism spectrum disorder in Qatar: The BARAKA-Qatar Study
Published 2023“…</p><h3>Results</h3><p dir="ltr">Overall, we identify potentially pathogenic variants in known genes or regions in 27 out of 100 families (27%), of which 11 variants (40.7%) were classified as pathogenic or likely-pathogenic based on American College of Medical Genetics (ACMG) guidelines. …”
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