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L1-CAM knock-down radiosensitizes neuroblastoma IMR-32 cells by simultaneously decreasing MycN, but increasing PTEN protein expression
Published 2016“…Tumorsphere formation is one of the indicators of aggressiveness in malignant cancers, which was significantly inhibited in IMR-32 cells after L1-CAM KD or Sutent treatment, however, no synergistic effect was observed with dual treatments, rather L1-CAM KD alone showed a greater inhibition on tumorsphere formation compared to Sutent treatment alone. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Optimizing the construction team’s performance The influence of an agile project manager on a construction project team’s Success
Published 2023“…The United Arab Emirates, particularly the Emirates of Dubai, is one of the world's leading cities in mega projects, characterized by their modernity and speed compared to the rest of developed countries. The aggressive competition between the leading developers among the horizontal spread and high-rise buildings in this city is one of the most obvious things for construction experts and even residents. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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A Correlation between Theoretical and Actual Column Shortening and Lateral Sway in a Vertically Asymmetric High-Rise Concrete Building
Published 2016“…The consideration of columns shortening in high-rise buildings becomes more complex and needs more attention when the building is vertically asymmetric. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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A comparative analysis to forecast carbon dioxide emissions
Published 2022“…<p dir="ltr">Despite the growing knowledge and commitment to climate change, carbon dioxide (CO<sub>2</sub>) emissions continue to rise dramatically throughout the planet. In recent years, the consequences of climate change have become more catastrophic and have attracted widespread attention globally. …”
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Hydrodynamic Modelling of Sharjah lagoons (UAE) under Climate Changes
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The behavior of Tapered High Strength Concrete Filled Steel Tube (CFST) Column connected to Encased Steel Reinforced Concrete Composite (SRC) Column
Published 2020“…The purpose of having two different sections along the column height is to enhance the flexure resistance of the column at the top edge by introducing CFST element, while the lower part is modeled as SRC element and it is mainly subjected to axial compression with significant reduction in bending moments compared to the top part of the column. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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Comparing metabolic profiles between female endurance athletes and non-athletes reveals differences in androgen and corticosteroid levels
Published 2022“…<p dir="ltr">Endurance training is associated with physiological changes in elite athletes, but little is known about female-specific effects of endurance training. Despite the significant rise in female sports participation, findings from studies performed on male athletes are largely extrapolated to females without taking into consideration sex-specific differences in metabolism. …”
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Comparative cost assessment of sustainable energy carriers produced from natural gas accounting for boil-off gas and social cost of carbon
Published 2020“…Including social cost of carbon (SCC) within the total cost of transporting the energy of natural gas, the transportation cost of liquid ammonia is 1.11 $/GJ, whereas LNG transportation cost rises significantly to 1.68 $/GJ at SCC of 137 $/t CO<sub>2</sub> eq. …”
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Comparative Study on Beneficial Effects of Hydroxytyrosol- and Oleuropein-Rich Olive Leaf Extracts on High-Fat Diet-Induced Lipid Metabolism Disturbance and Liver Injury in Rats
Published 2020“…Equally, it showed a rise of the apoptotic markers (a decrease in the expression of the Bcl-2 and an increase of the P53). …”
