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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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Extended Preoperative Chemotherapy Does Not Improve Pathologic Response and Increases Postoperative Liver Insufficiency After Hepatic Resection for Colorectal Liver Metastases
Published 2010“…Results Treatment consisting of ≥9 cycles was not associated with an increase in complete or major pathologic response (SD vs. …”
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Intraocular pressure trends following intravitreal injections of anti-VEGF agents for diabetic macular edema
Published 2013“…Although there was no significant difference in the baseline IOPs betweenthe IOP rise group (mean 15.76 ; SD=3.18) vs. the rest of the eyes (mean 17.34 (SD= 3.48), p: 0.071), final IOP was significantly higher in the IOP rise group (mean 18.65 vs.16.81, p 0.047). …”
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The Immunophenotyping Changes of Peripheral CD4+ T Lymphocytes and Inflammatory Markers of Class III Obesity Subjects After Laparoscopic Gastric Sleeve Surgery – A Follow-Up Study...
Published 2021“…LGS caused a significant reduction in BMI by 32%, p< 0.0001. LGS intervention significantly decreased CD4+ T-lymphocytes and effector memory (TEM) cells but increased T-regulatory (Treg), naïve, and central memory (TCM) cells, with all p values < 0.05. …”
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Heart Rate Variability Analysis Reveals a Non-monotonic Relationship between Humanin Concentration and Cardiac Autonomic Regulation
Published 2022“…A mitohormetic type of relationship was observed with HRV features increasing and then decreasing with increasing HN concentration. …”
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β-2-himachalen-6-ol protects against skin cancer development in vitro and in vivo
Published 2017“…A significant decrease in protein levels of p53 and Bcl-2 and a significant increase in p21 and Bax were observed. …”
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A meta‐analysis of the educational effectiveness of three‐dimensional visualization technologies in teaching anatomy
Published 2014“…Based on 2,226 participants including 2,128 from studies with comparison groups, 3DVTs (1) resulted in higher (d = 0.30, 95%CI: 0.02–0.62) factual knowledge, (2) yielded significant better results (d = 0.50, 95%CI: 0.20–0.80) in spatial knowledge acquisition, and (3) produced significant increase in user satisfaction (d = 0.28, 95%CI = 0.12–0.44) and in learners' perception of the effectiveness of the learning tool (d = 0.28, 95%CI = 0.14–0.43). …”
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Validation of Polygenic Risk Scores for Coronary Heart Disease in a Middle Eastern Cohort Using Whole Genome Sequencing
Published 2022“…</p><h3>Results</h3><p dir="ltr">The majority of PRSs performed well; odds ratio (OR) per 1 SD increase (OR1sd) was highest for PGS000337 (OR1sd=1.81, 95% CI [1.66–1.98], <i>P</i>=3.07×10−41). …”
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How FIFA World Cup 2022™ can meet the carbon neutral commitments and the United Nations 2030 Agenda for Sustainable Development?: Reflections from the tree nursery project in Qatar...
Published 2023“…</p> <h2>Other Information</h2> <p>Published in: Sustainable Development<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br> See article on publisher's website: <a href="http://dx.doi.org/10.1002/sd.2239" target="_blank">http://dx.doi.org/10.1002/sd.2239</a></p>…”
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Renewable Energy, Coal as a Baseload Power Source, and Greenhouse Gas Emissions: Evidence from U.S. State-Level Data
Published 2017“…It is estimated that a 10% increase in the share of renewable energy could decrease CH4 emissions by about 0.26%. …”
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