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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Spatial Distribution and Abundance of Emerging Microplastics Pollutants in Groundwater of UAE
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Spatial and temporal assessment of metal pollution in the sediments of the Qaraoun reservoir, Lebanon
Published 2016“…Total metal concentrations and the environmental indices indicated increased pollution with time. Total organic carbon data showed a remarkable and significant increase in the organic fraction in 2013 relative to previous years. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Modeling electricity consumption patterns during the COVID-19 pandemic across six socioeconomic sectors in the State of Qatar
Published 2021“…The results also show that there were variations of spatial clustering of electricity consumption among these sectors. …”
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Spatial modelling of contribution of individual level risk factors for mortality from Middle East respiratory syndrome coronavirus in the Arabian Peninsula
Published 2017“…The odds of dying from the disease was found to increase as age increased beyond 25 years and was much higher for individuals with any underlying comorbidities.…”
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Geospatial assessment of the carbon footprint of water and electricity consumption in residential buildings in Doha, Qatar
Published 2024“…Furthermore, the findings underscore the significant impact of residential structures, especially villas, on Doha's CF emissions, revealing a marked seasonal increase, particularly during the summer months and a notable spike in 2020. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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Mapping subnational HIV mortality in six Latin American countries with incomplete vital registration systems
Published 2021“…</p><h3>Conclusions</h3><p dir="ltr">Our subnational estimates of HIV mortality revealed significant spatial variation and diverging local trends in HIV mortality over time and by age. …”
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Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990–2019: a systematic analysis...
Published 2021“…Although prevalence of smoking had decreased significantly since 1990 among both males (27·5% [26·5–28·5] reduction) and females (37·7% [35·4–39·9] reduction) aged 15 years and older, population growth has led to a significant increase in the total number of smokers from 0·99 billion (0·98–1·00) in 1990. …”
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Modeling electricity consumption patterns during the COVID-19 pandemic across six socioeconomic sectors in the State of Qatar
Published 2021“…The results also show that there were variations of spatial clustering of electricity consumption among these sectors. …”
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Unveiling the Nexus Between Land Use, Land Surface Temperature, and Carbon Footprint: A Multi-Scale Analysis of Building Energy Consumption in Arid Urban Areas
Published 2024“…The findings reveal significant correlations between higher LST, reduced green spaces, and increased CF in residential and commercial sectors. …”
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Urban Geometry: The Effect of Height Diversity and Buildings Configuration on Thermal Performance and Cooling Load at Urban Scale. A Case Study in Dubai / UAE
Published 2018“…Therefore, designing the urban block with a significant diversity in building heights, or gradual height variation will have the potential of a shading effect and wind speed increase to enhance the thermal performance of the urban block. …”
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Shared Clean Mobility Operations for First-Mile and Last-Mile Public Transit Connections: A Case Study of Doha, Qatar
Published 2022“…Results indicate that public transit ridership can increase up to 17%. Moreover, adding the carpooling option can significantly decrease the number of relocations operations at a minimal impact on the commuters’ trip performance.…”