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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Local arterial vasoconstriction induced by octreotide in patients with cirrhosis
Published 2000“…FBF in the control arm was unchanged despite a significant decrease in systemic glucagon levels. Methacholine infusion increased FBF around 300%, which was not altered by the concomitant infusion of octreotide. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Recent advances in the treatment and outcome of locally advanced rectal cancer
Published 1999“…Background Preoperative therapy has been used in locally advanced rectal cancer to preserve sphincter function, decrease local recurrence, and improve survival. …”
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A Survey of Indoor Localization Systems for Multi-Floor Environments
Published 2025“…As a result, multi-floor localization systems capable of identifying the user’s floor as well have recently gained significant attention. …”
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Adapting to Climate Risk? Local Population Dynamics in the United States
Published 2024“…We also find that the agglomeration is largely driven by increases in the (white) working-age population. In addition, we show that high-risk tracts have typically grown more than low-risk tracts <i>within</i> the same county, suggesting the presence of highly localized amenities. …”
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Nonlinear effects in locally resonant nanostrip phononic metasurface at GHz frequencies
Published 2021“…Finite element analysis reveals that the device operates in a vertically polarized (compression) mode with substantial acoustic energy confined in the nanostrips, leading to a local resonance at low acoustic velocity. Due to the nonlinearity, the resonance frequency of the device decreases with the increase in stimulation power. …”
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Workforce localization and HRM practices in the Gulf countries: a literature review
Published 2015“…As members of the Gulf Cooperation Council (GCC), the states of Bahrain, Kuwait, Qatar, Oman, Saudi Arabia and the United Arab Emirates pursue localization as a government policy aimed at increasing the participation of national citizens in the private sector. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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Additive manufacturing for vernacular architecture using local earthen soil and bio-waste materials
Published 2025“…<p dir="ltr">The construction industry heavily relies on ordinary portland cement (OPC), contributing significantly to global carbon emissions while offering poor thermal insulation. …”
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