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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …”
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Stress Management Using Physiological Signals and Audio Stimulation
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The sympathetic baroreflex is enhanced during emotional stress in rats
Published 2007“…Under both conditions, baroreflex function curves relating AP and RSNA were constructed by fitting a sigmoid function to RSNA and AP measured during sequential nitroprusside and phenylephrine administrations. Air-jet stress significantly (P<0.01) increased the mean levels of AP (from 112 +/- 2 to 124 +/- 2 mmHg), heart rate (from 381 +/- 10 to 438 +/- 18 beats/min) and RSNA (from 0.80 +/- 0.14 to 1.49 +/- 0.23 microV). …”
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
Published 2025“…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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A cafeteria diet modifies the response to chronic variable stress in rats
Published 2012“…In addition, there was a significant interaction between stress and diet on serum corticosterone levels, which manifest as an increase in corticosterone levels in stressed rats relative to non-stressed controls in the HC and HF groups but not in the CAF group. …”
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Alleviation of drought and salt stress in vegetables: crop responses and mitigation strategies
Published 2022“…<p dir="ltr">In recent decades, the demand for vegetables has increased significantly due to the blooming global population. …”
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Exploring Effects of Mental Stress with Data Augmentation and Classification Using fNIRS
Published 2025“…Notably, after augmenting the data with DCGAN, the classification accuracy increases dramatically to 96%. In the time series data, statistically significant differences were noticed in the data before and after BB stimulation, which showed an improvement in the brain state, in line with the classification results. …”
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Environmental enrichment and cafeteria diet synergistically modify the response to chronic variable stress in rats
Published 2013“…Stressed animals showed increased serum corticosterone (CORT) levels compared to non-stressed animals (P<0.001). …”
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Waterpipe Tobacco Smoke Nicotine Mediates Resilience to Chronic Stress by Activating BDNF Signaling
Published 2020“…Finally, we showed that nicotine mediates the effects of WTS only on resilience to stress by increasing BDNF and TRKB levels and signaling. …”
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The Effects of the COVID-19 Pandemic on Undergraduate Students’ Stress and Anxiety in a University in the UAE
Published 2021“…First-year students were significantly more stressed than second-year, third-year, and fourth-year students. …”
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Sensibilisation du baroréflexe sympathique durant le stress émotionnel chez le rat
Published 2007“…Under both conditions, baroreflex function curves relating AP and RSNA were constructed by fitting a sigmoid function to RSNA and AP measured during sequential nitroprusside and phenylephrine administrations. Air-jet stress significantly (P ≪ 0.01) increased the mean levels of AP (from 112 ± 2 to 124 ± 2 mmHg), heart rate (from 381 ± 10 to 438 ± 18 beats/min) and RSNA (from 0.80 ± 0.14 to 1.49 ± 0.23 µV). …”
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Cardiovascular impact of post-traumatic stress disorder: A systematic review and meta-analysis
Published 2024“…<h3>Background</h3><p dir="ltr">Post-traumatic stress disorder (PTSD) is increasingly recognized for its effects beyond mental health, with emerging evidence suggesting a significant association with cardiovascular diseases (CVD). …”
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Baroreflex control of renal sympathetic nerve activity during air-jet stress in rats
Published 2007“…The RSNA-AP relationship was shifted toward higher AP values, and its maximum gain was significantly (P < 0.01) increased from 9.0 ± 1.3 to 16.2 ± 2.1 normalized units (NU)/mmHg. …”
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