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Increasing methylation of sperm rDNA and other repetitive elements in the aging male mammalian germline
Published 2020“…Here, we used bisulfite pyrosequencing and show that methylation of the rDNA transcription unit including upstream control element (UCE), core promoter, 18S rDNA, and 28S rDNA in human sperm also significantly increases with donor's age. This positive correlation between sperm rDNA methylation and biological age is evolutionarily conserved among mammals with widely different life spans such as humans, marmoset, bovine, and mouse. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Deep aging clocks: AI-powered strategies for biological age estimation
Published 2025“…<p>Several strategies have emerged lately in response to the rapid increase in the aging population to enhance health and life span and manage aging challenges. …”
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Aging Effects in Field-Compacted Dredged Material
Published 2013“…The addition of SSF to the 100% DM resulted in significant pH buffering and in strength increases up to a factor of 2, as measured by the average cone penetrometer test (CPT) tip resistance. …”
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Perinatal factors impacting echocardiographic left ventricular measurement in small for gestational age infants: a prospective cohort study
Published 2023“…<h2>Introduction</h2><p dir="ltr">Infants born small for gestational age (SGA) have an increased risk of developing various cardiovascular complications. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Effect of consanguinity on birth weight for gestational age in a developing country
Published 2007“…No significant difference was observed in the decrease in birth weight between the first- and second-cousin marriages. …”
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Association between Healthy Lifestyle Index and Cognitive decline In Community- Dwelling Lebanese Older Adults
Published 2021“…Objective: Normal aging is often associated with cognitive deterioration in older adults, but the prevalence of cognitive decline like cognitive impairment, Alzheimer’s disease and dementia has been increasing lately. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Crisis Management and Crisis Communication in the Digital Age: The Impact of Social Media
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Health Care Accessibility of Lebanese Working-Age Adults with Musculoskeletal Disability
Published 2016“…The diversity of the Lebanese society increased after the 1975-1990 civil war, the grapes of Wrath conflict and July 2006 war. …”
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Effects of paternal and chronological age on BEGAIN methylation and its possible role in autism
Published 2023“…<p dir="ltr">Children from old fathers carry an increased risk for autism spectrum (ASD) and other neurodevelopmental disorders, which may at least partially be mediated by paternal age effects on the sperm epigenome. …”
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The Association of Hypertension with Increased Mortality Rate During the COVID-19 Pandemic: An Update with Meta-analysis
Published 2023“…In addition, a combination of other comorbidities and old age appears to increase the risk of mortality from COVID-19.…”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Impact of body composition analysis on male sexual function: A metabolic age study
Published 2023“…Although erectile dysfunction (ED) and hypogonadism are increasingly prevalent with age, they are also detected among younger men. …”