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Cardiac phosphodiesterases are differentially increased in diabetic cardiomyopathy
Published 2021“…However, DCM was not associated with changes in PDE4A gene expression irrespective of the disease stage. Significance We show for the first time differential and time-specific regulations in cardiac PDEs, data that may prove useful in proposing new therapeutic approaches in T1D-induced DCM.…”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…”
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Characterization of exercise-induced hemolysis in endurance horses
Published 2023“…Blood plasma was collected before and after the competition and analyzed macroscopically, by ELISA and non-targeted metabolomics with liquid chromatography–mass spectrometry. A significant increase in all hemolysis parameters was observed after the race, and an association was found between the measured parameters, average speed, and distance completed. …”
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Prevalence and clinical significance of antiphospholipid antibodies in patients with coronavirus disease 2019 admitted to intensive care units: a prospective observational study
Published 2022“…<p>Coronavirus disease 2019 (COVID-19) increases the risk of coagulopathy. Although the presence of antiphospholipid antibodies (aPLs) has been proposed as a possible mechanism of COVID-19-induced coagulopathy, its clinical significance remains uncertain. …”
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Local arterial vasoconstriction induced by octreotide in patients with cirrhosis
Published 2000“…FBF in the control arm was unchanged despite a significant decrease in systemic glucagon levels. Methacholine infusion increased FBF around 300%, which was not altered by the concomitant infusion of octreotide. …”
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Hyperthyroidism‐Induced Nondiabetic Ketoacidosis: A Rare Case Report
Published 2025“…Our patient's symptoms significantly improved with propranolol and carbimazole treatment. …”
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Internet Searches for Medical Symptoms Before Seeking Information on 12-Step Addiction Treatment Programs: A Web-Search Log Analysis
Published 2019“…Specifically, symptom queries were first determined to be significantly predictive of subsequent 12-step queries if the probability of querying a medical symptom by those who later sought information about the 12-step program exceeded the probability of that same query being made by a comparison group of all other Bing users in the United States. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…Flow cytometric analysis revealed that both fractions induced the accumulation of cells in the sub-G1 phase, increase in apoptotic cell death and chromatin condensation. …”
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Metabolic Profiling of Exercise-induced Autophagy-dependent Metabolites in Mouse Plasma
Published 2024“…Our results show that exercise induced distinct metabolic changes in mouse plasma, with several metabolites, including pregeijerene, androsterone glucuronide, meproscillarin, and N-acetyl methionine, showing significant increases in the exercise group. …”
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The effects of Cucurbita pepo seeds on testosterone induced benign prostatic hyperplasia
Published 2011“…Additionally, no significant effects were observed on levels of sGOT-AST enzyme and ALP, while slight increase was observed on sGPT-AST. …”
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Fermentation-induced modifications to the structural, surface, and functional properties of quinoa proteins
Published 2025“…Notably, fermentation significantly increases the digestibility of QPs from 78.13 to 85.24%, thereby enhancing their nutritional value. …”
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DNA damage induced by micellar-delivered doxorubicin and ultrasound: comet assay study
Published 2000“…However, when ultrasound was applied, a rapid and significant increase in DNA damage was observed (P=0.0001). …”
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Molecular Mechanisms of Adiponectin-Induced Attenuation of Mechanical Stretch-Mediated Vascular Remodeling
Published 2020“…Mechanical stretch significantly increased p-ERK1/2 after 10 minutes, whereas APN significantly reduced stretch-induced ERK1/2 phosphorylation. …”
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Peripherally injected cholecystokinin-induced neuronal activation is modified by dietary composition in mice
Published 2010“…In addition, a significant interaction was found between CCK administration and the HF diet, shown by an increased activation in the PVN, which suggests a decrease the inhibiting action of CCK. …”
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Cardioprotective effect of Sanguisorba minor against isoprenaline-induced myocardial infarction in rats
Published 2023“…Histopathological studies of the cardiac tissue showed isoprenaline-induced injury that was significantly attenuated by the extract.…”
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Morphological changes in amblyopic eyes in choriocapillaris and Sattler’s layer in comparison to healthy eyes, and in retinal nerve fiber layer in comparison to fellow eyes through...
Published 2021“…Results The method of measuring reflectivity is good to excellent reliability for all regions of interest except the fourth. The mean reflectivity of the choriocapillaris and Sattler’s layer in amblyopic eyes were significantly lower than in healthy eyes (p = 0.003 and p = 0.008 respectively). …”
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Phosphorus supplementation recovers the blunted diet-induced thermogenesis of overweight and obese adults
Published 2016“…Overweight/obese subjects had a blunted DIT with placebo, while P supplementation induced a 23% increase in their DIT area under the curve (p < 0.05), which was associated with a significant increase in carbohydrate oxidation. …”
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