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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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Silver-based dressings for the prevention of surgical site infections: evidence from randomized trials
Published 2025“…<h3>Background</h3><p dir="ltr"><u>Surgical site infections</u> (SSIs) are a major cause of <u>postoperative complications</u>, increasing morbidity and healthcare costs. …”
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Spatial modelling of contribution of individual level risk factors for mortality from Middle East respiratory syndrome coronavirus in the Arabian Peninsula
Published 2017“…A Geoadditive variable model for binary outcomes was applied to account for both individual level risk factors as well spatial variation via a fully Bayesian approach.…”
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Incidence, risk factors and outcomes of nosocomial infection in adult patients supported by extracorporeal membrane oxygenation: a systematic review and meta-analysis
Published 2024“…Secondary endpoints included time to infection, source of infection, ECMO duration, Intensive care and hospital length of stay (LOS), ECMO survival and overall survival. …”
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SARS‐CoV‐2 infection and effects of age, sex, comorbidity, and vaccination among older individuals: A national cohort study
Published 2023“…Risk of infection varied minimally by age and sex but increased significantly with coexisting conditions. …”
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Efficacy and Safety of Colistin versus Tigecycline for Multi-Drug-Resistant and Extensively Drug-Resistant Gram-Negative Pathogens—A Meta-Analysis
Published 2022“…We pooled odd ratios (OR) using heterogeneity-guided random or fixed models at a statistical significance of <i>p</i> < 0.05. …”
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Virome-wide serological profiling reveals association of herpesviruses with obesity
Published 2021“…<p>The relationship between viral infection and obesity has been known for several decades but epidemiological data is limited to only a few viral pathogens. …”
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Effectiveness of pharmacist-led antimicrobial stewardship programs in perioperative settings: A systematic review and meta-analysis
Published 2024“…A meta-analysis was conducted using a random-effect model. </p><h3>Results </h3><p dir="ltr">Eleven studies were included in this review. …”
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Diabetic Foot Ulcer Detection: Combining Deep Learning Models for Improved Localization
Published 2024“…Our method utilizes innovative model ensemble techniques—non-maximum suppression (NMS), Soft-NMS, and weighted bounding box fusion (WBF)—to combine predictions from state-of-the-art object detection models. …”
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Hybrid Model for Detection of Cervical Cancer Using Causal Analysis and Machine Learning Techniques
Published 2022“…It is improved from of random forest method and mainly discovers feature subsets from the data source that are significant to assigned classification activity. The proposed model’s primary aim is to determine the importance of cervical cancer screening factors for classifying high-risk patients depending on the findings. …”
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The Role of Government Hospital During the COVID-19 Pandemic
Published 2024“…Additionally, 20 Powered Air Purifying Respirators significantly enhanced healthcare workers' safety.</p><h3>Conclusion</h3><p dir="ltr">The comprehensive strategy, and strict infection prevention measures, significantly improved patient care and healthcare workers’ safety during the COVID-19 response. …”
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PFDI: a precise fruit disease identification model based on context data fusion with faster-CNN in edge computing environment
Published 2023“…The results show that the model size with 60–90% pruning can be counteracted to the 47.64 of the baseline model without significant loss of accuracy. …”
