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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…”
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Evidence and gaps in clinical outcomes of novel pharmacologic therapies for sickle cell disease: A systematic literature review highlighting insights from clinical trials and real-...
Published 2025“…Real-world studies of crizanlizumab showed a reduction in complicated VOC events. The high discontinuation rate and results of the STAND trial led to a significant decrease in the use of crizanlizumab. …”
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Developing a Framework for Designing and Assessing Professional Development in Educational Technology : A Study in a Private School in the UAE
Published 2024“…The integration of technology in education is essential for enhancing learning experiences and preparing students for a technology-driven world. …”
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The impact of stakeholder integration on large-scale, innovative PPP infrastructure projects
Published 2020“…Despite the importance of stakeholder management in PPP projects, it has not yet received significant attention, this thesis seeks to address this gap in our current knowledge by holistically examining stakeholder integration (SI) in PPP innovative projects, as the integration of stakeholders between all parties is essential to the success of PPP projects, especially if it is innovative. …”
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Framework for Mapping Internal Stakeholder Dynamics in Driving Green Innovation Strategies in the UAE Oil & Gas Sector
Published 2025“…In contrast, employee engagement showed no major influence, underscoring the need for greater empowerment and involvement of employees in sustainability initiatives. …”
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Risk Assessment in Construction Projects: Integrating Five Dimensions of Risk
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INTEGRATING TRADITIONAL AND UNCONVENTIONAL CSR THEORIES AND MODELS – A THEORETICAL
Published 2020“…The surge in financial scandals, widening gaps in social inequality, increasing political and financial muscle by MNC’s, global uncertainties as well as environmental degradation has put the spotlight on firms to strengthen their involvement and be sensitive to socially responsible activities. …”
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Exploring Academic Integrity in Primary Education: Challenges, Strategies, and Impact
Published 2023“…Key findings highlight the significance of explicit instruction, clear policies, positive school culture, and parental involvement in fostering academic integrity. …”
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Challenges, Opportunities, and Success Factors of Integrating Video Production Education in Lebanon
Published 2023“…This research investigates the challenges, opportunities, and success factors associated with integrating video production education in Lebanon. The study aims to explore the experiences of teachers and students involved in video production courses, examining their perspectives before and after the workshop. …”
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masterThesis
