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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Mapping subnational HIV mortality in six Latin American countries with incomplete vital registration systems
Published 2021“…</p><h3>Conclusions</h3><p dir="ltr">Our subnational estimates of HIV mortality revealed significant spatial variation and diverging local trends in HIV mortality over time and by age. …”
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Significance of microscopically incomplete resection margin after esophagectomy for esophageal cancer
Published 2016“…There were significant differences between the groups in postoperative histology, with an increase in pathological stage III and TRG 4–5 in the R1 group. …”
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Hedonic valuation of land protection methods: implications for cluster development.
Published 2014“…The key findings of the study are: (i) proximity to national or state park land and to city or county open space has a significant positive impact on property values, while proximity to national forest land or to privately conserved land exhibits no significant effects; and, (ii) inclusion of a property within a cluster development decreases its value by 17 to 26 %. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…In this regard, engineering of brighter bioluminescent proteins, i.e. luciferases, has played a significant role. This is acutely exemplified by the engineering of the NLuc <u>luciferase</u>, which is small in size and displays much enhanced bioluminescence and<u> thermal stability</u> compared to previously available luciferases. …”
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Accessibility of large events: an empirical study of the Expo 2020 Dubai
Published 2024“…The objective of this paper is to contribute to understanding the accessibility of large events in an increasingly technology-dependent industry. …”
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Small molecule inhibition of stat3 enhances survival in mice with intracerebral melanoma
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A GRASP Approach for Solving Large-Scale Electric Bus Scheduling Problems
Published 2021“…The results also show that high speed chargers have a more significant impact than an increase in battery sizes of the EBs.…”
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Suppression of Unstable Flow by Using Rough Surfaces at Small Mass Flow Rates in a Radial Diffuser
Published 2006Get full text
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Aerosol Optical Thickness over Large Urban Environments of the Arabian Peninsula—Speciation, Variability, and Distributions
Published 2019“…Over the past decade, the mean annual aerosol optical thickness (AOT) values were in the range of 0.3–0.5, which is attributed to both mineral dust (60–70%) and anthropogenic activities (20–30%). An increase in AOT values between 2005 and 2009 is attributed to increased dust generation from the Sahel region in Northern Africa, and the Fertile Crescent (Syria, Iraq, Jordan) due to an extended dry period. …”
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Optimizing the number of players and training bout durations in soccer small‐sided games: Effects on mood balance and technical performance
Published 2025“…Therefore, coaches should consider longer continuous bouts when planning SSGs‐based training to significantly decrease TMD and enhance technical‐tactical performance in soccer SSGs.…”
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Ethnic-specific association of amylase gene copy number with adiposity traits in a large Middle Eastern biobank
Published 2021“…Indeed, lower AMY1 CN was associated with increased total and trunk fat percentages in Arabs (P < 4.60 × 10−3) but not in Persians. …”
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Benthic development on large-scale engineered reefs: a comparison of communities among breakwaters of different age and natural reefs
Published 2011“…Breakwaters represent large-scale engineered artificial reefs that can develop diverse and abundant communities and are likely to play an increasing role in marine ecosystems as human populations grow in coastal urban areas. …”
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