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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Increased Levels of Circulating and Tumor-Infiltrating Granulocytic Myeloid Cells in Colorectal Cancer Patients
Published 2016“…<p dir="ltr">Increased levels of myeloid cells, especially myeloid-derived suppressor cells (MDSCs), have been reported to correlate with bad prognosis and reduced survival in cancer patients. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…Furthermore, treatment of MDA-MB-231 cells with either fraction significantly reduced the level of phosphorylated Erk but did not show any effect on phosphorylated Akt. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Western blotting results revealed an upregulation in Bax:Bcl‑2 ratio, confirming the pro‑apoptotic effect of kefir, and an increase in p53 independent‑p21 expression upon kefir treatment. …”
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Increased levels of CSF total but not oligomeric or phosphorylated forms of alpha-synuclein in patients diagnosed with probable Alzheimer’s disease
Published 2017“…CSF total α-syn (t-α-syn) significantly increased in the AD group (p < 0.0001) compared to controls, while oligomeric- and phosphorylated-Ser129-α-syn did not change significantly. …”
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Effect of increasing the number of anchors on the flexural performance of FRP-strengthened RC beams
Published 2024“…This study aims to investigate the effect of increasing the number of FRP spike anchors at the laminate's ends on the flexural behavior of strengthened and anchored RC beams. …”
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Significance of Avicennia Marina in the Arabian Gulf Environment: A Review
Published 2025“…However, in the past two decades Gulf mangroves have been facing significant threats, including extensive coastal development, shoreline modification by establishing marinas and ports, and climate change-associated impacts such as sea-level rise and altered precipitation patterns, which pose significant risks to this fragile ecosystem. …”
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The effect of vancomycin doses greater than 2 grams on serum creatinine and vancomycin trough levels
Published 2014“…The use of doses greater than 2 grams of IV vancomycin did not show a statistically significance increase in serum creatinine. The two subjects who did have a significant increase in serum creatinine were receiving concomitant nephrotoxins. …”
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Cardiac phosphodiesterases are differentially increased in diabetic cardiomyopathy
Published 2021“…Upregulation of β1-AR receptor transcripts was noted in diabetic hearts at 4 weeks along with an increase in cAMP levels and an upregulation in the ejection fraction and fraction shortening. …”
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The Role of Project Management Soft Skills in Increasing Project Success
Published 2017“…As the world economy shifts towards an increasingly globalised market, the degree of competition becomes a more significant challenge which organisations face. …”
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Cyclosporine lymphocyte maximum level
Published 2005“…Clinical outcome was compared according to CsA LTmL, dosage, blood trough (C0) and maximum (Cmax) levels, hematocrit level, and LC. Results: Rejecting patients had significantly lower LTmL than did those with normal graft function (27 ± 11 pg/Lc vs 71 ± 79 pg/Lc; P < 0.01) and similar LTmL to those with nephrotoxicity (27 ± 8 pg/Lc). …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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