Air pollution burden of disease over highly populated states in the Middle East by Rima J. Isaifan (8350056)

Revisiting high-density lipoprotein cholesterol in cardiovascular disease: Is too much of a good thing always a good thing? by Mohammad Al Zein (20090700)

“…Despite the correlation between low high-density lipoprotein cholesterol (HDLC) and heightened CVD risk, HDL-raising therapies have yet to showcase significant clinical benefits. …”

Tumor-Infiltrating Lymphoid Cells in Colorectal Cancer Patients with Varying Disease Stages and Microsatellite Instability-High/Stable Tumors by Salman M. Toor (8854751)

“…We investigated the expression of immune checkpoints (ICs) on lymphoid populations within the CRC TME and compared with cells from normal colon tissues using samples from 50 patients with varying disease stages. We found that the levels of B cells, T cells, and NK cells were similar, IC-expressing CD4+ and CD4+CD8+ double positive T cells were higher, while CD8+ T cells and CD4−CD8− double negative T cells were significantly lower in CRC tumors. …”

Association of coronary artery disease and chronic kidney disease in Lebanese population by Milane, Aline

“…This correlation remained highly significant despite considerable inter-patient variability and was at its highest at the most advanced stages of both diseases. …”
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Disease-Associated α-Synuclein Aggregates as Biomarkers of Parkinson Disease Clinical Stage by Nour Majbour (3528548)

“…<h3>Background and Objectives</h3><p dir="ltr">Robust biomarkers that can mirror Parkinson disease (PD) are of great significance. In this study, we present a novel approach to investigate disease-associated α-synuclein (αSyn) aggregates as biomarkers of PD clinical stage.…”

Tryptophanyl-tRNA synthetase-1 (WARS-1) depletion and high tryptophan concentration lead to genomic instability in Caenorhabditis elegans by Mahmoud Izadi (12899508)

“…Our result demonstrates that exposing C. elegans to a high tryptophan dosage leads to DNA damage checkpoint activation and a significant increase in the tryptophan metabolites. …”

Stemming cardiovascular diseases in Qatar by Nature Research (16552612)

“…Many of the heart attack and stroke patients had diabetes, hypertension, high cholesterol, and/or were smokers, whereas controls were much less likely to have these factors.…”

Mixed precision iterative refinement with adaptive precision sparse approximate inverse preconditioning by Noaman Khan (19810050)

“…<p dir="ltr">Hardware trends have motivated the development of mixed precision algorithms in numerical linear algebra, which aim to decrease runtime while maintaining acceptable accuracy. …”

Aortic stiffness, kidney disease, and renal transplantation by Bahous, Sola Aoun

“…In subjects with chronic kidney disease (CKD), treatment of high systolic blood pressure is a key element in preventing disease progression and the occurrence of cardiovascular (CV) events. …”
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Parkinson’s disease and schizophrenia interactomes contain temporally distinct gene clusters underlying comorbid mechanisms and unique disease processes by Kalyani B. Karunakaran (12478431)

“…<p dir="ltr">Genome-wide association studies suggest significant overlaps in Parkinson’s disease (PD) and schizophrenia (SZ) risks, but the underlying mechanisms remain elusive. …”

Dietary patterns in cardiovascular diseases prevention and management by Dimassi, Hani

“…The significance of this type of research to primary care physicians is also highlighted. …”
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Olodaterol for the treatment of chronic obstructive pulmonary disease by Ramadan, Wijdan H.

“…Olodaterol (Striverdi Respimat, Boehringer Ingelheim), a LABA with high selectivity for β2-adrenergic receptors, is indicated for the treatment of chronic obstructive pulmonary disease (COPD); the recommended dose is 5 µg, to be delivered once daily via the Respimat inhaler. …”
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Minor Intron Splicing from Basic Science to Disease by Ettaib El Marabti (23276158)

“…Consequently, uncovering how mi-INTs splicing is regulated in a tissue-specific manner would allow for better understanding of disease pathogenesis and pave the way for novel therapies, which we highlight in this review.…”

Association between dental diseases and history of stroke in the United States by Hatem A. Alhadainy (14153157)

“…Multiple logistic regression modeling was used to estimate the effect of these dental diseases on the self-reported history of stroke with intent to adjust for the other potential determinants: age, sex, race, marital status, health insurance, education, exercise, body mass index, smoking, alcohol, hypertension, high serum cholesterol, and diabetes.…”

Allergic rhinitis: Disease characteristics and coping measures in Saudi Arabia by Almehizia, Abdulmohsin A.

“…Background Despite allergic rhinitis (AR) being a highly prevalent disease, according to literature, it is often underdiagnosed or undertreated. …”
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Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019 by Gregory A. Roth (6302315)

“…<p>Cardiovascular diseases (CVDs), principally ischemic heart disease (IHD) and stroke, are the leading cause of global mortality and a major contributor to disability. …”

Serum 25-hydroxyvitamin D concentrations are inversely associated with body adiposity measurements but the association with bone mass is non-linear in postmenopausal women by Vijay, Ganji

“…In a continuous variable analysis, the association between 25(OH)D and bone mass was significant, non-linear, inverse ‘U’. In conclusion, serum 25-hydroxyvitamin D was inversely associated with adiposity measures and non-linearly associated to bone mass in postmenopausal Qatari women.…”
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Serum 25-hydroxyvitamin D concentrations are inversely associated with body adiposity measurements but the association with bone mass is non-linear in postmenopausal women by Vijay Ganji (8710491)

“…In a continuous variable analysis, the association between 25(OH)D and bone mass was significant, non-linear, inverse ‘U’. In conclusion, serum 25-hydroxyvitamin D was inversely associated with adiposity measures and non-linearly associated to bone mass in postmenopausal Qatari women.…”

Epigenetic DNA Methylation Signatures Associated With the Severity of Paget’s Disease of Bone by Ilhame Diboun (3522413)

“…Additionally, methylation profiles in 11 regions showed Bonferroni-significant association with disease severity including six islands (located in VCL, TBX5, CASZ1, ULBP2, NUDT15 and SQSTM1), two gene bodies (CXCR6 and DENND1A), and 3 promoter regions (RPL27, LINC00301 and VPS29). …”

Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson’s disease by Nour K. Majbour (8809316)

“…<h3>Background</h3><p dir="ltr">Despite decades of intensive research, to date, there is no accepted diagnosis for Parkinson’s disease (PD) based on biochemical analysis of blood or CSF. …”