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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…In this regard, engineering of brighter bioluminescent proteins, i.e. luciferases, has played a significant role. This is acutely exemplified by the engineering of the NLuc <u>luciferase</u>, which is small in size and displays much enhanced bioluminescence and<u> thermal stability</u> compared to previously available luciferases. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Prediction of evaporation losses in wet cooling towers
Published 2020“…Accurately predicting evaporation losses is significant because water in cooling towers is cooled primarily through the evaporation of a portion of the circulating water, which causes the concentration of dissolved solids and other impurities to increase. …”
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Modeling of photovoltaic soiling loss as a function of environmental variables
Published 2017“…Higher WS typically favored more positive daily ΔCI when RH was low, but at higher RH levels (>50%) daily ΔCI was more likely to be negative with increasing WS. In fact, high RH levels were related to negative daily ΔCI only at higher WS levels (>2ms−1); at lower WS levels RH had no significant effect on daily ΔCI. …”
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Exploring Beyond Numeric Weight Loss: The Metabolic Effects of Semaglutide.
Published 2025“…It also significantly reduced ad libitum energy intake, decreased hunger, and increased satiety in multiple trials. …”
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Exploring beyond numeric weight loss: The metabolic effects of semaglutide
Published 2025“…</u> It also significantly reduced ad libitum <u>energy intake</u>, decreased hunger, and increased satiety in multiple trials. …”
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The genetic basis and the diagnostic yield of genetic testing related to nonsyndromic hearing loss in Qatar
Published 2024“…The prevalence of hereditary hearing loss increases in consanguineous populations, and the prevalence of hearing loss in Qatar is 5.2%. …”
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Small molecule inhibition of stat3 enhances survival in mice with intracerebral melanoma
Published 2008Get full text
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Otosyphilis: A rare case of reversible hearing loss in a young man with secondary syphilis
Published 2023“…<h3>Background</h3><p dir="ltr">Over the last decade, it has been noticed a significant increase in the number of cases of syphilis with a concurrent increased number of patients presenting with syphilis-related complications. …”
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Suppression of Unstable Flow by Using Rough Surfaces at Small Mass Flow Rates in a Radial Diffuser
Published 2006Get full text
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Optimizing the number of players and training bout durations in soccer small‐sided games: Effects on mood balance and technical performance
Published 2025“…Therefore, coaches should consider longer continuous bouts when planning SSGs‐based training to significantly decrease TMD and enhance technical‐tactical performance in soccer SSGs.…”
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Loss of FOXA2 induces ER stress and hepatic steatosis and alters developmental gene expression in human iPSC-derived hepatocytes
Published 2022“…Lack of FOXA2 resulted in significant alterations in the expression of key developmental and functional genes in hepatic progenitors (HP) and mature hepatocytes (MH) as well as an increase in the expression of ER stress markers. …”
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Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function
Published 2017“…Staining of breast cancer cases for MMP-8 revealed a statistically significant loss of MMP-8 expression in DCIS with invasion versus pure DCIS (<i>p</i> = 0.001).…”
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A Framework for Project Time-Cost Optimization Considering Float Consumption Impact
Published 2012Get full text
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Outcomes of drain versus no drain in total knee arthroplasty: a retrospective cohort study
Published 2023“…The aim of this study is to compare the outcomes of patients who received suction drains versus those who did not, focusing on blood loss, blood transfusion need, and length of hospital stay.…”
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Design analysis and experimental validation of a multi‐level inverter for vehicle to home application
Published 2023“…<p dir="ltr">Robust and economic inverting devices are needed with the increasing practice of direct current (DC) sources. …”