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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Detection of statistically significant network changes in complex biological networks
Published 2017“…The proposed procedure exploits a more effective model selection criteria to generate <i>p</i>-values for statistical significance and is more efficient in terms of computational time and prediction accuracy than literature methods. …”
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Scaffold‑based 3D cell culture models in cancer research
Published 2024“…Three-dimensional (3D) cell cultures have emerged as valuable tools in cancer research, offering significant advantages over traditional two-dimensional (2D) cell culture systems. …”
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Across the Spectrum In-Depth Review AI-Based Models for Phishing Detection
Published 2024“…These attacks can be detected using both traditional and modern AI-based models. However, even with state-of-the-art methods, accurately classifying newly emerged links as phishing or legitimate remains a challenge. …”
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Neural network based predistortion of radio frequency power amplifiers
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Effect of corporate ethics and social responsibility on OCB: the role of employee identification and perceived CSR significance
Published 2021“…Based on the data analysis results, the model is validated and the stated hypotheses are supported. …”
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A Unified Model-Based Framework for the Simplified Execution of Static and Dynamic Assertion-Based Verification
Published 2020“…In order to simplify its execution, various Model Based System Engineering approaches provide a higher abstraction layer. …”
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Dynamic mechanical characterization and modelling of polypropylene based organoclay nanocomposite
Published 2015“…A three-phase approach based on the micromechanical formulation of the cooperative model is proposed to model the yield behaviour of the polymer nanocomposite. …”
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Forecasting model to predict project success based on the contractors’ characteristics
Published 2018Get full text
doctoralThesis
