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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Cardiac phosphodiesterases are differentially increased in diabetic cardiomyopathy
Published 2021“…However, DCM was not associated with changes in PDE4A gene expression irrespective of the disease stage. Significance We show for the first time differential and time-specific regulations in cardiac PDEs, data that may prove useful in proposing new therapeutic approaches in T1D-induced DCM.…”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…In this regard, engineering of brighter bioluminescent proteins, i.e. luciferases, has played a significant role. This is acutely exemplified by the engineering of the NLuc <u>luciferase</u>, which is small in size and displays much enhanced bioluminescence and<u> thermal stability</u> compared to previously available luciferases. …”
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Small molecule inhibition of stat3 enhances survival in mice with intracerebral melanoma
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The effects of Organisational Ambidexterity and New Public Management on Public Sector Service Quality through Service Innovation
Published 2020“…Moreover, the bureaucratic structure of the public sector hinders any initiative to improve, meet the demand for better products and services and operate without necessarily increasing its expenditures and disbursements. Hence, the need to reduce bureaucracy may give rise to the increasing demand for service innovation to attain service quality and enhance performance. …”
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Suppression of Unstable Flow by Using Rough Surfaces at Small Mass Flow Rates in a Radial Diffuser
Published 2006Get full text
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Can "Whatsapp" be the new luxury "app"? (c2018)
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Natural resource dependence and war nexus: new insights
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A New Method for Generalizing Burr and Related Distributions
Published 2022“…The models of this newly introduced generalized Burr family can significantly increase the flexibility of the former Burr distribution with respect to the density and hazard rate shapes. …”
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Optimizing the number of players and training bout durations in soccer small‐sided games: Effects on mood balance and technical performance
Published 2025“…Therefore, coaches should consider longer continuous bouts when planning SSGs‐based training to significantly decrease TMD and enhance technical‐tactical performance in soccer SSGs.…”
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Lipsome-coated metal organic frameworks as a new drug nanocarrier
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New susceptibility loci associated with type 2 diabetes. (c2011)
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The Effects of New Public Management on Managers’ Work-Life Balance and Behavior
Published 2020“…The main differing factors included the manner in which NPM was implemented and the negative attitude of the participants when faced with an increasing workload. The key significance of the present study lies in its difference from prior research carried out in other contexts. …”
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Morphological changes in amblyopic eyes in choriocapillaris and Sattler’s layer in comparison to healthy eyes, and in retinal nerve fiber layer in comparison to fellow eyes through...
Published 2021“…Results The method of measuring reflectivity is good to excellent reliability for all regions of interest except the fourth. The mean reflectivity of the choriocapillaris and Sattler’s layer in amblyopic eyes were significantly lower than in healthy eyes (p = 0.003 and p = 0.008 respectively). …”
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