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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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The relationship between sleep duration and health status in Qatar’s population
Published 2020“…Qatar’s population exhibited high prevalence of short sleep duration, which was significantly associated with poor rated health, obesity, and chronic illness independent of age, gender, or social class.…”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Adapting to Climate Risk? Local Population Dynamics in the United States
Published 2024“…We also find that the agglomeration is largely driven by increases in the (white) working-age population. In addition, we show that high-risk tracts have typically grown more than low-risk tracts <i>within</i> the same county, suggesting the presence of highly localized amenities. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Investigating vulnerability for developing eating disorders in a multi-confessional population
Published 2016“…Affiliating as Christian was found to significantly decrease the vulnerability to developing an ED. …”
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Country of birth affects blood pressure in the French hypertensive diabetic population
Published 2015“…In a population of 56,242 individuals living in France, we showed that individuals born in France have significantly different levels of blood pressure (BP) and cardiovascular (CV) risk factors than African and Asian populations born in their own country but living long-term in France (average duration of stay, 5–10 years). …”
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Landscape of childhood epilepsies – A multi-ethnic population-based study
Published 2022“…</p><h3>Significance </h3><p dir="ltr">This large multi-ethnic population-based study confirms that the prevalence, incidence and clinical features of epilepsy in Qatar is in accordance with other epidemiologic studies and highlights risk factors for the development of co-morbidities and medically-intractable epilepsy.…”
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Multivariate epidemiologic analysis of type 2 diabetes mellitus risks in the Lebanese population
Published 2014“…Results: The prevalence of T2DM significantly increased with increasing BMI (p < 0.0001). …”
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Maternal and Neonatal Outcomes Post Bariatric Surgery: A Population-Based Study
Published 2023“…On the other hand, obesity significantly increased the risk of gestational diabetes, cesarean deliveries, and labor induction in comparison to the other groups.…”
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The hazardous impacts of mining activities on population's health in Blue Nile State - Sudan
Published 2014“…Serum level of chromium in the Jam area population was P < 0.05, copper and cobalt were P>0.05; and the values were found to be in normal reference range, except for chromium which was found to be slightly increased in Jam area. …”
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Association of genetic polymorphisms in FTO with Overweight/Obesity and Type 2 Diabetes in the Lebanese Population
Published 2021“…Conclusion: The rs17817499 variant of the FTO gene was highly associated with overweight and obesity in the Lebanese population. On the other hand, the studied FTO variants were not significantly associated with T2DM. …”
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National-level and state-level prevalence of overweight and obesity among children, adolescents, and adults in the USA, 1990–2021, and forecasts up to 2050
Published 2024“…The prevalence of obesity has outpaced the increase in overweight over time, especially among adolescents. …”
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