A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity by Wesam S. Ahmed (10170053)

“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”

Decreased Analgesic Requirements in Super Morbidly Versus Morbidly Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy by Hamed Elgendy (14148846)

Both decreasing interstructural space size and increasing total cover increase shrimp abundance on artificial structures deployed in a UAE seagrass bed by Bartholomew, Aaron

Get full text

Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex by Wesam S. Ahmed (10170053)

“…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…”

L1-CAM knock-down radiosensitizes neuroblastoma IMR-32 cells by simultaneously decreasing MycN, but increasing PTEN protein expression by Rached, Johnny

Get full text
Get full text
Get full text
Get full text

Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells by Nihal AlMuraikhi (6002234)

“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”

The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu... by Wesal Habbab (17346961)

“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”

Serum Vitamin D Concentration ≥75 nmol/L Is Related to Decreased Cardiometabolic and Inflammatory Biomarkers, Metabolic Syndrome, and Diabetes; and Increased Cardiorespiratory Fitn... by Vijay Ganji (8710491)

Patients with early onset of type 1 diabetes have significantly higher GG genotype at position 49 of the CTLA4 gene by Zalloua, Pierre

“…The GG genotype was also significantly higher among patients (12.6%) than in controls (4.2%). χ2 analysis and family-based association studies were performed and suggested the association of CTLA4 exon 1 G polymorphism with T1D (p = 0.0229). …”
Get full text
Get full text
Get full text

Assessing uncertainty in image-based monitoring: addressing false positives, false negatives, and base rate bias in structural health evaluation by Vagelis Plevris (14158863)

“…The Base Rate Bias plays a significant role, as low probabilities of actual damage often lead to misinterpretation of positive results. …”

A component analysis of positive behaviour support plans by Grey, Ian

“…Method Sixty-one staff working with individuals with intellectual disability and challenging behaviours completed longitudinal competency-based training in PBS. Each staff participant conducted a functional assessment and developed and implemented a PBS plan for one prioritised individual. …”
Get full text
Get full text
Get full text
Get full text

An evaluation of positive behavioural support for people with very severe challenging behaviours in community-based settings by Grey, Ian M.

Get full text
Get full text
Get full text
Get full text

HER2-positive apocrine carcinoma of the breast: a population-based analysis of treatment and outcome by Faruk Skenderi (6616190)

“…HER2+/SR−/APO had a significantly lower histological grade than the HER2+/SR−/NST (p < 0.001). …”

Addition of sphingosine-1-phosphate to human oocyte culture medium decreases embryo fragmentation by Zreik, Tony

Get full text
Get full text
Get full text

Evaluating the impact of a brief Health at Every Size-informed health promotion activity on body positivity and internalized weight-based oppression by Lily, O’Hara

“…The aim of this study was to evaluate the impact of a brief health promotion activity informed by Health at Every Size- and critical health promotion principles on body positivity and internalized weight-based oppression in female students at Qatar University. …”
Get full text
Get full text
Get full text

Structure-activity relationships of copper-based metal-organic Frameworks: Investigating antibacterial mechanisms against gram-positive and gram-negative bacteria by Muhammad Hubab (20639153)

“…<u>Transmission Electron Microscopy</u> (TEM) analysis verified the significant <u>biocidal</u> activity of Cu-MOFs against both the Gram-negative (<i><u>Escherichia coli</u></i>) and Gram-positive (<u>Staphylococcus aureus</u> and <i>Bacillus subtilis</i>) bacteria, by disrupting their cell membranes and inducing cell death primarily through Cu²⁺ <u>ion release</u>. …”

Structure-Activity Relationships of Copper-Based Metal-Organic Frameworks: Investigating Antibacterial Mechanisms against Gram-Positive and Gram-Negative Bacteria by Muhammad Hubab (20639153)

“…Transmission Electron Microscopy (TEM) analysis verified the significant biocidal activity of Cu-MOFs against both the Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus and Bacillus subtilis) bacteria, by disrupting their cell membranes and inducing cell death primarily through Cu²⁺ ion release. …”

Optimizing patellar positioning during total knee arthroplasty by Deeb, Mary

“…Medialization of the prosthetic patella has been recommended; however, no evidence-based guidelines have been reported. Material and method This anatomical study aims to quantify a pre-defined optimal location for positioning of the patellar component with regard to the centre of the patellar cut. …”
Get full text
Get full text
Get full text

Applications of bioconvection for tiny particles due to two concentric cylinders when role of Lorentz force is significant by Lei Zhang (38117)

Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment by Amal Sabouni (17046236)

“…In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …”