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Factors Influencing the Magnitude and Clinical Significance of Drug Interactions Between Azole Antifungals and Select Immunosuppressants
Published 2006“…Differences in metabolism and in the inhibitory potency of cytochrome P450 3A4 and Pglycoprotein influence the onset, magnitude, and resolution of drug interactions and their potential effect on clinical outcomes. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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The Influence of Risks on the Performance of E-Business
Published 2016“…The practitioner could get an insight from this study to help prioritize the e-Business risk and assign a correct probability of occurrence as well as the significance of the risk impact. The e-Business risk construct framework with its six e-business modules used in this research present a limitation in the context that not all e-Business firm or practitioners necessarily get involved with the six e-Business modules, which might influence the respondent perception and risk rating. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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The potential of technology in education. (c2016)
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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Exploring the Transformative Potential of Generative AI in Mechanical Engineering Education
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Adoption of blockchain technology in healthcare systems: benefits, potential applications, and challenges
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Numerical investigation of the potential of using hydrogen as an alternative fuel in an industrial burner
Published 2024“…Mass flow rate (MFR) adjustments and excess air variation significantly influenced emissions, with a 25% MFR increase reducing NOx to 2.8 × 10<sup>-5</sup>, while higher excess air (e.g.,30%) raised NO<sub>x</sub> under lean conditions. …”
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The Influence of Risks on the Success of the Development and Installation of Temporary Structure in Event Projects in Dubai
Published 2017“…Research finding shows that risks arise during Erection phase are likely to be crucial as risks present the most significant influence on the success of temporary structure project, followed by risks during Pre-Erection phase. …”
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Enhancing Mesenchymal Stromal Cell Immunomodulation for Treating Conditions Influenced by the Immune System
Published 2019“…Thus, immunosuppressive treatment with MSCs has been proposed as a potential therapeutic alternative for conditions in which the immune system cells influence outcomes, such as inflammatory and autoimmune diseases. …”
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Growth, Yield and Water Productivity of Tomato as Influenced by Deficit Irrigation Water Management
Published 2023“…The results showed that physiological traits, yield, and water productivity were significantly influenced by irrigation system and soil moisture regime. …”
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Role of Exosome in Solid Cancer Progression and Its Potential Therapeutics in Cancer Treatment
Published 2025“…</p><h3>Conclusion</h3><p dir="ltr">Exosomes play a pivotal role in solid cancer progression and offer significant potential in advancing our understanding of tumor biology. …”