Circulating and Tumor-Infiltrating Immune Checkpoint-Expressing CD8+ Treg/T Cell Subsets and Their Associations with Disease-Free Survival in Colorectal Cancer Patients by Alhasan Alsalman (14802873)

“…We found that FoxP3 expression and ICs including PD-1, CTLA-4, TIM-3, and LAG-3 were significantly increased in tumor-infiltrating CD8+ T cells compared with NT and peripheral blood. …”

Predictors of prolonged hospitalization among geriatric trauma patients using the modified 5-Item Frailty index in a Middle Eastern trauma center: an 11-year retrospective study by Husham Abdelrahman (768893)

“…Head injury and bleeding were the leading causes of mortality in the study cohort. There was a significant decrease in the trend of geriatric trauma over the years. …”

Investigating the Role of Acetyl-CoA Synthetase Short Chain Family Member 2 (ACSS2) in Inflammatory Bowel Disease: Expression in Clinical Samples and Insights from In Vitro Models by Mezher, Nawal

“…In this study, immunohistochemistry of colon samples from UC patients revealed significantly elevated expression and nuclear localization of ACSS2 in inflamed tissues compared to non-inflamed regions, suggesting its involvement in IBD pathogenesis. …”
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OSRA Grant Cycle 5 Public Reports : Project Title: Coping with prenatal bereavement and perceived stress in current pregnancy: correlates to parental perception of the child and bo... by Pia Tohme Khalaf (17425551)

Activation of Src kinase in primary colorectal carcinoma An indicator of poor clinical prognosis by Allgayer, Heike

“…The primary tumor-to-normal mucosa ratios of activity were compared following classification and regression tree (CART) analysis to determine the prognostic significance of elevated specific Src activity. Expression of u-PAR was correlated with Src activity. …”
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Stromal TRIM28-associated signaling pathway modulation within the colorectal cancer microenvironment by Seán Fitzgerald (721911)

“…Low TRIM28 epithelium to stroma ratios were associated with elevated levels of caspases 3 and 7 in stroma (p = 0.041 and p = 0.036) and an increased signaling pathway similarity in stromal cells with 81 significant Spearman correlations (ρ ≥ 0.75, p ≤ 0.01).…”

Cadmium-induced endothelial dysfunction mediated by asymmetric dimethylarginine by Hamda A. Al-Naemi (14151675)

“…Interestingly, the expression of eNOS in the Cd-treated group was found to be significantly elevated during the exposure by more than 3-fold in comparison with that in the control group. …”

Immunoprofile of childhood diabetes by Meritxell Espino-Guarch (15430868)

“…When transcriptomic data was interrogated, an imbalance between ITGA4/ ITGB1 was observed in all groups where CD49d showed increased expression. Associated with these findings, anti-inflammatory Treg cytokines including IL-10 were decreased in T2D patients and elevated plasma levels of IL-17, which contributes to the insulin resistance and inflammation were observed.…”

Transcriptome of Tumor-Infiltrating T Cells in Colorectal Cancer Patients Uncovered a Unique Gene Signature in CD4+ T Cells Associated with Poor Disease-Specific Survival by Salman M. Toor (8854751)

“…High ppScore patients showed lower expression of Treg-, Th1-, and Th17-related genes, and higher expression of Th2-related genes. …”

Characteristic MicroRNAs Linked to Dysregulated Metabolic Pathways in Qatari Adult Subjects With Obesity and Metabolic Syndrome by Fayaz Ahmad Mir (11828354)

“…Six out of the thirteen demonstrated significant association with HbA1c levels; miR-331-3p, miR-452-3p, and miR-485-5p were over-expressed, whereas miR-153-3p, miR-182-5p, and miR-433-3p were under-expressed in the OBM patients with elevated HbA1c levels. …”

<i>CCN3</i>,<i> POSTN</i>, and <i>PTHLH</i> as potential key regulators of genomic integrity and cellular survival in iPSCs by Nuha T. Swaidan (18595219)

“…RT-qPCR validation confirmed elevated <i>CCN3</i> and<i> PTHLH</i> expression in A53T-PD1 iPSCs, aligning with RNA-seq findings. …”

Do near-bedtime usage of smartphones and problematic internet usage really impact sleep? A study based on objectively recorded usage data by Aftab Alam (5158601)

“…</p><h3> Results</h3><p dir="ltr">The multivariate linear regression showed that the increase in PIU (β = −0.231, p < 0.001) and smartphone usage two hours before sleep (β = −0.246, p < 0.001) led to decrease in sleep duration. Regarding sleep distraction, multivariate linear regression analysis revealed that two hours before sleep was a significant and positive predictor of sleep distraction (β = 0.197, p = 0.003), whereas PIU was not significant. …”

Sleeping habits during COVID-19 induced confinement: A study from Jordan by Mahmoud A. Alomari (14780446)

“…In addition, gender (p < 0.001) is an independent predictor of nighttime sleeping. Being a male is associated with a “decrease” and being a female is associated with an “increase” in nighttime sleeping hours (p < 0.05). …”

MicroRNA-3148 acts as molecular switch promoting malignant transformation and adipocytic differentiation of immortalized human bone marrow stromal cells via direct targeting of the... by Radhakrishnan Vishnubalaji (3563306)

“…Bioinformatics analysis revealed that elevated miR-3148 expression correlates with poor prognosis in several human cancer types, including sarcoma. …”

In vivo assessment of the nephrotoxic effects of the synthetic cannabinoid AB-FUBINACA by Ayman Alzu’bi (13162392)

“…Administration of AB-FUBINACA was found to be associated with a significant increase in the expression of oxidative stress markers (iNOS, NOX4, NOX2, NOS3) and the level of lipid peroxidation in the kidney. …”

RFX3 is essential for the generation of functional human pancreatic islets from stem cells by Bushra Memon (4792767)

“…The loss of <i>RFX3</i> disrupted pancreatic endocrine gene regulation, reduced the number of hormone-secreting islet cells and impaired beta cell function and insulin secretion. Despite a significant reduction in the expression levels of pancreatic islet hormones, the pan-endocrine marker chromogranin A remained unchanged at both EP and islet stages, likely due to an increase in the abundance of enterochromaffin cells (ECs). …”

Effects of Social Media Use and Dependence on Dietary Intake and Prevalence of Orthorexia in Pregnant and Non-Pregnant Women by Issa, Yara

“…However, social media use was not significantly associated with orthorexia. Regression analyses showed that both social media use (p<0.001) and having a social media account (p=0.023) were predictors of reduced intuitive eating, with social media use being the most significant predictor. …”
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Comparative Study on Beneficial Effects of Hydroxytyrosol- and Oleuropein-Rich Olive Leaf Extracts on High-Fat Diet-Induced Lipid Metabolism Disturbance and Liver Injury in Rats by Ines Fki (14571855)

“…The hepatic immunohistochemical analysis revealed a significant increase in the expression of inflammatory genes (COX-2, NF-<em>κ</em>B, and TNF-<em>α</em>). …”

Claudins in ovarian cancer: emerging biomarkers and therapeutic targets by Lubna Therachiyil (4246156)

“…In OC, several claudins are overexpressed relative to normal ovarian tissue. These elevated expression observed among OC subtypes indicates their potential utility as diagnostic biomarkers. …”

Synthetic Cannabinoid AB-FUBINACA Negatively Impacted the Male Fertility and Induced Testicular Toxicity by Ayman Alzu’bi (13162392)

“…These findings were associated with higher level of oxidative stress (GP91 expression and malondialdehyde level) and elevated expression of key regulators of apoptosis (Bax and caspase-3) as well as reduced expression of mitochondrial respiratory chain complexes SDHB (II), UQCRC2 (III), and ATP5a (V) in the testicular tissue.…”