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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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The Role of Project Management Soft Skills in Increasing Project Success
Published 2017“…As the world economy shifts towards an increasingly globalised market, the degree of competition becomes a more significant challenge which organisations face. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Further, analysis of trajectories for <u>hydrogen bonds</u> (H-bonds) formed between NLuc and furimazine revealed substantial H-bond interaction between R162 and Q32 residues. Mutation of the two residues in NLuc revealed a decreased but stable activity of the R162A, but not Q32A, mutant NLuc in live cell and in vitro assays performed using lysates prepared from cells expressing the proteins and with the furimazine substrate. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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A clustering metaheuristic for large orienteering problems
Published 2022“…The metaheuristic aims to dramatically improve the computation time of a given Orienteering Problem algorithm without a significant decrease in the solution quality of that algorithm, especially for large Orienteering Problems. …”
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Partnering for Sustainability: Parent-Teacher-School (PTS) Interactions in the Qatar Education System
Published 2021“…Furthermore, while almost all parents recognize the significance of parental involvement and show a high level of interest in being on the ‘Board of Trustees’, in reality, very few participate or volunteer in school activities, and they rarely visit classrooms or interact with teachers or schools, mainly due to their increasing job-related commitments. …”
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Analysis and Design of Circular Shafts Using Finite Element Method
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The Interactions of Business Environment, Generic Strategy, Operations Strategy, and Business Performance in the Lebanese Industries
Published 2021“…The results confirmed the significance of the direct effects at the aggregate level. …”
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Characterization of the dynamic flow response in microfluidic devices
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A GRASP Approach for Solving Large-Scale Electric Bus Scheduling Problems
Published 2021“…The results of the conducted computational experiments indicate that an increase in infrastructure investment through high speed chargers can significantly decrease the size of the necessary fleets. …”
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Interactions of black carrot concentrate powder as a natural coloring agent with gelatine and sucrose in model gummy samples
Published 2025“…BCCP x gelatin and BCCP × sucrose interactions were determined to be significant for texture parameters such as hardness, gumminess, chewiness, and L∗, a∗, b∗, and chroma values (P < 0.05). …”
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The Influence of Performance Management Feedback on Employee Performance: The Moderating Role of Organizational Justice and its Dimensions (Procedural, Distributive, Interactional)
Published 2025“…In modern organizations, providing feedback is critical for increasing employee performance; nevertheless, little is known about how performance management feedback quality influences employee performance. …”
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Structural interactions of complex proteins with trehalose: mechanisms for improving the multilevel structure and functional properties of lentil-quinoa protein complexes
Published 2024“…The method involved manipulating protein interactions through pH shifting and the addition of trehalose, ultimately enhancing water solubility, digestibility, and the functionality. …”
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An Improved Genghis Khan Optimizer based on Enhanced Solution Quality Strategy for Global Optimization and Feature Selection Problems
Published 2024“…The algorithm presented aims to solve the FS problem and has been assessed using benchmark optimization problems from the CEC’2017 and CEC’2022. …”
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The Effect of the Variation of the Modulus of Subgrade Reaction on the Design of Large Shallow Foundations
Published 2022“…With the use of variable coefficient across the mat foundation, a significant decrease in the steel reinforcement is witnessed and an optimized/ more adapted steel distribution is observed.…”
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Dynamic Hybrid Cross-Docking Model with Multiple Truck Types
Published 2015Get full text
doctoralThesis