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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …”
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Programming Effects of Short Prenatal Exposure to Dexamethasone in Sheep
Published 2002“…Most interestingly, the mechanism leading to programming of hypertension might be linked with the brain angiotensin system. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
Published 2025“…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …”
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The Impact of Learning Computer Programming on the Development of High School Students Cognitive Abilities in the UAE
Published 2019“…Twelve cognitive abilities were studied in a mixed-methods research; induction, general sequential reasoning, quantitative reasoning, memory span, working memory, visualization, speed rotation, closure speed, flexibility of closure, visual memory, spatial scanning, and serial perceptual integration. additionally, the researcher had studied students’ choices, perceptions, and classroom practices and linked them to their cognitive style indices. The results revealed that students demonstrated a significant improvement in their induction, quantitative reasoning, closure speed, visual memory, and serial perceptual integration cognitive abilities. furthermore, students demonstrated confidence and positive attitude toward learning programming. however, students’ awareness of the usefulness of learning programming and their motivation to learn it was not evident. there was no significant impact of gender on students’ choices of studying programming. on another hand, students’ cognitive style index who chose to study programming was more analytic than intuitive. yet, male students were more analytic than females. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…While most PDAs close after one 3-day course of either medicine, a repeat course may be necessary before considering surgical ligation for those who remain with hsPDAs. In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Optimization metaheuristic for software testing
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‘The newest vital sign among pregnant women attending women wellness and research Centre in Qatar: a cross-sectional study’
Published 2022“…Furthermore, the insufficient level of health literacy was significantly associated with low educational background, decreased household income, and primigravida. …”
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The Effect of HuArgI (Co)-PEG5000 on The Migration of Ovarian Cancer
Published 2020“…HuArgI (Co)-PEG5000 is a potential drug to target cancers that depend on exogenous sources of arginine and cannot synthesize their own. In this study, we hypothesized that HuArgI (Co)- PEG5000 can decrease the migration of ovarian cancer cells. …”
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The Effectiveness of Teaching Reading (Meta) Cognitive Strategies in Improving UAE Grade-12 Students’ Reading Comprehension Proficiency for School-based Tests and University Admiss...
Published 2015“…The results of the study have indicated a statistically significant effect of strategy-based instruction in improving the learners’ reading comprehension performance, and confirmed a significant correlation between language proficiency and learning the reading strategies. …”
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Pharmacist-led educational interventions provided to healthcare providers to reduce medication errors: A systematic review and meta-analysis
Published 2023“…Educational programs led by a pharmacist were associated with significant reductions in the overall rate of medication errors occurrence (OR, 0.38; 95% CI, 0.22 to 0.65).…”
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Enhancing the Indoor Lighting Quality of U.A.E Museums A Case Study of Louvre Abu Dhabi
Published 2021“…Furthermore, museums play a significant role in spreading the concept and awareness of sustainability, both through design and through exhibited items. …”
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The Effect of Recombinant Anthrax Lethal Toxin on Breast Cancer Cell Motility, Adhesion, and Invasion
Published 2020“…Cells treated with LT showed a significant decrease in motility as seen in 2D time-lapse and wound healing assays. …”
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masterThesis
