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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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Predicting tendon tissue grafting source from the extensors of long fingers
Published 2018“…Predicting the possible tendon sources that could be present on the dorsum of the hand is thought to be very valuable for hand surgeons. In addition and from an evolutionary perspective, we hypothesized that the observed significantly higher frequency values of the double-slip and triple-slip types of the EDC of the ring finger, EDC of the little finger, and EDM might indicate a natural selection tendency for a higher independence of the former digits in the future evolution of the human hand.…”
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Viral metagenomics analysis of stool specimens from children with unresolved gastroenteritis in Qatar
Published 2022“…<p dir="ltr">Acute gastroenteritis (AGE) is associated with significant global morbidity and mortality, especially among children under five years of age. …”
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Evaluation and management of complications from synthetic mesh after pelvic reconstructive surgery
Published 2014“…Conclusion Most of the women who seek management of synthetic mesh complication after POP or SUI surgery have severe complications that require surgical intervention; a significant proportion require >1 surgical procedure. …”
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Evaluation of particulate matter emissions from non-passenger diesel vehicles in Qatar
Published 2020“…Despite itsimportance, there are significant challenges in the quantitative evaluation of its contribution toairborne concentrations. …”
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Corporate governance and effect in fintech: Evidence from Gulf Cooperation Council banking sector
Published 2023“…<p dir="ltr">This study looks at the banking sector in the Gulf Cooperation Council (GCC) from 2013 to 2021 to determine the impact that corporate governance had on financial innovation, as well as the impact that financial innovation had on performance. …”
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Utilization of the evidence from studies with no events in meta-analyses of adverse events: an empirical investigation
Published 2022“…Systematic reviews published at present (2015-2020) tended to incorporate zero-events studies in meta-analyses than those published in the past (2008-2011), but the difference was not significant (proportion difference=−0.09, 95% CI −0.21 to 0.03, p = 0.12).…”
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From past famines to present crises: The epigenetic impact of maternal malnutrition on offspring health in Gaza
Published 2024“…</p><p dir="ltr"><br></p><p dir="ltr">The nutritional impact of famine on pregnant women in the Gaza region presents significant adverse consequences (Elnakib et al., 2024). …”
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Does the CEO effect differ in times of crisis? Evidence from US and China during the global financial crisis
Published 2024“…Utilizing multilevel modeling on a 15-year dataset of US firms and assessing three performance metrics, we identify a significant decline (increase) in the CEO effect on accounting-based (market-based) performance measures (measure) from the pre-crisis to the crisis period, followed by a significant rebound post-crisis. …”
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School children growth monitoring program in the state of Qatar: Observations from two survey rounds in 2016–17 and 2019–20
Published 2023“…</p><h3>Results</h3><p dir="ltr">Overall, the proportion of overweight and obese category of students increased from 44% in 2016–17 to 49.3% in 2019–20 with a decrease in the proportion of students in normal BMI‐z‐score category (from 48.8% to 47.8%) and severe thinness and thinness category (from 7.3% to 3%) between two rounds of growth monitoring survey. …”
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