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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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A comparison of peer, teacher and self-feedback on the reduction of language errors in student essays
Published 2016“…Next, students sat for an immediate and a delayed post-test. Comparison of students' performance on pronoun agreement errors revealed that all groups increased the percentage of this error on the immediate post-test but decreased it on the delayed post-test, with no significant difference between the groups. …”
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Polarimetric SAR Speckle Reduction by Hybrid Iterative Filtering
Published 2020“…Speckle filtering in synthetic aperture radar polarimetry (PolSAR) is essential for the extraction of significant information. In this study, the authors introduced a hybrid iterative filtering scheme. …”
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Performance and microbial community variations of anaerobic digesters under increasing tetracycline concentrations
Published 2017“…In addition, the accumulation of propionate was due to an increase in volatile fatty acids (VFA)-producing bacteria coupled with a reduction in propionate utilizers. …”
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Friction Reduction in Elastohydrodynamic Contacts by Thin Layer Thermal Insulation
Published 2014“…It is shown that a few micrometer-thin DLC coating can significantly influence the thermal behavior in a lubricated mechanical system. …”
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Foreign Aid and the Quest for Poverty Reduction: Is Aid to Agriculture Effective?
Published 2013“…Our analysis uses panel data for developing aid recipient countries to empirically test this relationship. We find a significant relationship between agricultural aid and poverty reduction in our estimates.…”
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Efficient experimental design for uncertainty reduction in gene regulatory networks
Published 2015“…The proposed approximate method also outperforms the random selection policy significantly.</p><p dir="ltr">Erratum - Erratum to: Efficient experimental design for uncertainty reduction in gene regulatory networks: <a href="https://dx.doi.org/10.1186/s12859-015-0839-y" target="_blank">https://dx.doi.org/10.1186/s12859-015-0839-y</a>, published online 14 December 2015.…”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…”
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Mixed precision iterative refinement with adaptive precision sparse approximate inverse preconditioning
Published 2025“…Our numerical experiments show that this approach can potentially lead to a reduction in the cost of storing and applying sparse approximate inverse preconditioners, although a significant reduction in cost may comes at the expense of increasing the number of GMRES iterations required for convergence.…”
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